Evidence map›Paper›PMID 41018732›Full record

ArticleAging advances2025

Biological aging and its association with serum neurofilament light chain levels in middle-aged African Americans: a prospective observational study.

Man-Kit Lei, Mei Ling Ong, Ronald L Simons, Steven R H Beach

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Translational Geroscience Strategies for Delaying Multimorbidity.ACS pharmacology & translational science · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Man-Kit LeiDepartment of Sociology, University of Georgia, Athens, GA, USA.ORCID 0000-0002-7757-6548
Mei Ling OngCenter for Family Research, University of Georgia, Athens, GA, USA.
Ronald L SimonsDepartment of Sociology, University of Georgia, Athens, GA, USA.
Steven R H BeachDepartment of Psychology, University of Georgia, Athens, GA, USA.

Funding

Psychosocial Context and the Biological Clock: Changes in Weathering during Middle-AgeR01AG055393 · NIA · UNIVERSITY OF GEORGIA · PI SIMONS, RONALD L · 2017 to 2021
$3.4M
Stress, Weathering, and Blood-Based Biomarkers of Alzheimer’s Disease: A Longitudinal Study of Low Income, Aging African AmericansRF1AG077386 · NIA · UNIVERSITY OF GEORGIA · PI MIELKE, MICHELLE M, SIMONS, RONALD L · 2022 to 2023
$3.2M
Stress, Weathering, and Blood-Based Biomarkers of Alzheimer’s DiseaseR01AG077386 · NIA · UNIVERSITY OF GEORGIA · PI Steven R Beach, Michelle M Mielke · 2025 to 2026
$1.6M
NIA NIH HHS R01 AG055393NIA NIH HHS R01 AG077386NIA NIH HHS RF1 AG077386
6 · The paper itself

Abstract

This study examines the association between DNA methylation-based epigenetic aging indices and neurofilament light chain levels in middle-aged African Americans to advance the understanding of neurodegeneration and cognitive decline. Epigenetic aging was assessed in samples from 2008 and 2019 by applying HorvathAgeAccel, HannumAgeAccel, PhenoAgeAccel, GrimAgeAccel, and DunedinPACE. Controlling for financial strain, exercise, age, gender, cell-type composition, and

Indexed as

accelerated epigenetic agingagingDNA methylationneurodegenerationneurofilament light chain

Identifiers

PMID41018732
PMCPMC12462825

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.