Evidence map›Paper›PMID 41018945›Full record

ReviewThe Lancet regional health. Western Pacific2025

Pan-Asian consortium for treatment and research in ALS (PACTALS) guidelines for management of amyotrophic lateral sclerosis.

Steve Vucic, Nortina Shahrizaila, Osamu Kano, Parvathi Menon, Sheila Agustini, Kongkiat Kulkantrakorn, Nalini Atchayaram, Yi-Chung Lee, Mario B Prado, Kay W P Ng and 21 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet regional health. Western Pacific, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Steve VucicBrain and Nerve Research Centre, The University of Sydney, Sydney, Australia.
Nortina ShahrizailaDepartment of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Osamu KanoDepartment of Neurology, Toho University Faculty of Medicine, Tokyo, Japan.
Parvathi MenonBrain and Nerve Research Centre, The University of Sydney, Sydney, Australia.
Sheila AgustiniDepartment of Neurology, Mayapada Hospital, South Jakarta, Indonesia.
Kongkiat KulkantrakornNeurology Division, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathumtani, Thailand.
Nalini AtchayaramDepartment of Neurology, Neuroscience Faculty Center, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
Yi-Chung LeeDepartment of Neurology, Taipei Veterans General Hospital, School of Medicine National Yang Ming Chao Tung University, Taipei, Taiwan.
Mario B PradoDepartment of Physiology, University of the Philippines- College of Medicine, Manila, Philippines.
Kay W P NgDivision of Neurology, Department of Medicine, National University Hospital, Singapore.
Josiah ChaiDepartment of Neurology, National Neuroscience Institute (TTSH Campus), Singapore, Singapore.
Bugyeong SonCell Therapy Centre, Department of Neurology, Hanyang University Seoul Hospital, Seoul, Republic of Korea.
Paul TalmanDeakin University, University Hospital Geelong, Geelong, Victoria, Australia.
Hoang Tien Trong NghiaDepartment of Neurology, Military Hospital 175, Vietnam.
Le Tu Quoc TuanDepartment of Neurology, Trieu an Hospital, Vietnam.
Kazumoto ShibuyaDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yuishin IzumiDepartment of Neurology, Tokushima University Graduate School of Biomedical Sciences, Japan.
Naoki AtsutaDepartment of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan.
Robert D HendersonDepartment of Neurology, Royal Brisbane and Women's Hospital, Centre for Clinical Research, The University of Queensland, Brisbane, Australia.
Liying CuiDepartment of Neurology, Peking Union Medical College Hospital, Beijing, China.
Mingsheng LiuDepartment of Neurology, Peking Union Medical College Hospital, Beijing, China.
Ohnmar OhnmarDepartment of Neurology, Yangon General Hospital/University of Medicine 1, Myanmar.
Remli RabaniFaculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Yoon-Ho HongDepartment of Neurology, Seoul National University, College of Medicine; Seoul Metropolitan Government Boramae Medical Center, Republic of Korea.
Jung-Joon SungDepartment of Neurology, Seoul National University College of Medicine, Seoul National University Hospital, Republic of Korea.
Dongsheng FanDepartment of Neurology, Peking University Third Hospital, Beijing, 100191, China.
Veena RaykarConcord Repatriation General Hospital, Sydney, Australia.
Satoshi KuwabaraDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Seung Hyun KimDepartment of Neurology, College of Medicine, Hanyang University, Seoul, Republic of Korea.
Gen SobueAichi Medical University, Nagakute, Aichi, Japan.
Matthew C KiernanNeuroscience Research Australia, University of New South Wales, Margarete Ainsworth Building, Barker Street Randwick, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Pan-Asian Consortium for Treatment and Research in ALS (PACTALS) guidelines were developed for the management of amyotrophic lateral sclerosis (ALS) patients living in the Asia-Pacific countries, taking into consideration the ethnic, racial and economic diversity of the region. The majority of patients reside in low-income (limited-resource setting) and middle-income countries. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology was utilised for development of the PACTALS management guidelines. Nine broad research questions, divided into sections, were addressed. Evidence was derived from existing Cochrane reviews, systematic reviews, meta-analysis, and randomized controlled trials (RCT) along with consensus when evidence was limited. Recommendations were provided for diagnostic pathways, use of disease modifying therapies, appropriateness of multidisciplinary care models, management of respiratory dysfunction, communication and nutrition, addressing symptoms that affect the quality of life, managing cognitive, behavioural and emotional symptoms as well as appropriate implementation of palliative care services and addressing end-of-life issues. The PACTALS guidelines provide a much-needed framework for the management of ALS patients living in the Asia-Pacific region. The management guidelines will be updated as the treatment landscape evolves and evidence of novel management approaches becomes available.

Indexed as

ALSGRADEMNDPICO

Identifiers

PMID41018945
PMCPMC12465052

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.