Evidence map›Paper›PMID 41019289›Full record

ArticleBiochemistry and biophysics reports2025

LIN28-mediated gene regulatory loops synchronize transitions throughout organogenesis.

Indhujah Thevarajan, Maria F Osuna, Sonia Fuentes Lewey, Eustolia Sauceda, Sayra Briseno, Caylah Griffin, Bareun Kim, R Grant Rowe, Edroaldo Lummertz da Rocha, Jihan K Osborne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Indhujah ThevarajanDepartment of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.
Maria F OsunaDepartment of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.
Sonia Fuentes LeweyDepartment of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.
Eustolia SaucedaDepartment of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.
Sayra BrisenoDepartment of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.
Caylah GriffinDepartment of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.
Bareun KimDepartment of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.
R Grant RoweDivision of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA, 02115, USA.
Edroaldo Lummertz da RochaDepartment of Microbiology, Immunology and Parasitology (MIP), Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Jihan K OsborneDepartment of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.

Funding

Understanding the role of the lin28 paralogs and branching morphogenesisR01GM107536 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q · 2014 to 2017
$1.9M
Investigation of how RNA-directed feedback loops coordinate wound healing and regenerationR35GM160161 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Jihan K. Osborne · 2025 to 2026
$870k
NIGMS NIH HHS R01 GM107536NIGMS NIH HHS R35 GM160161
6 · The paper itself

Abstract

Control of the intervals between proliferation and differentiation of stem/progenitor cells is coordinated by developmental regulators, comprised of both microRNAs (miRNAs) and proteins, termed heterochronic genes. The heterochronic factors, Lin28-RNA-binding proteins (RBPs) and the miRNAs-

Identifiers

PMID41019289
PMCPMC12465051

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.