Evidence map›Paper›PMID 41019337›Full record

ArticleFrontiers in endocrinology2025

Haixia Huang, Yifei Yin, Yizhu Mao, Hong Li, Junjie Li, Mengxia Li, Yi Zhang, Xuandong Huang, Yifen Zhang, Chenxia Jiang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haixia Huang *Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
Yifei Yin *Department of Thyroid and Breast Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, The Second People's Hospital of Huai'an, Huai'an, China.
Yizhu MaoDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
Hong LiDepartment of Pathology, The Affiliated Huai'an Hospital of Xuzhou Medical University, The Second People's Hospital of Huai'an, Huai'an, China.
Junjie LiDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
Mengxia LiDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
Yi ZhangJiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Xuandong HuangDepartment of Thyroid and Breast Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, The Second People's Hospital of Huai'an, Huai'an, China.
Yifen ZhangJiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Chenxia JiangDepartment of Pathology, The Affiliated Hospital of Nantong University, Nantong, China.
Rongxi YangDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Differentiation between benign and malignant thyroid nodules has been a challenge in clinical practice. We aim to explore a novel biomarker to determine the malignancy of thyroid nodules. Methods: In the discovery study, 32 tissue samples from benign thyroid nodule (BTN) and thyroid cancer (TC) patients were analyzed by Methylation 850K array and RNA-Sequencing. TC associated Results: Altered and inversely correlated methylation and expression in the Conclusion: Our study suggested that altered

Indexed as

Biomarkers, TumorDNA MethylationFatty Acid Binding Protein 3Thyroid NeoplasmsThyroid NoduleAdultAgedDiagnosis, DifferentialFemaleHumansMaleMiddle AgedBiomarkers, TumorFABP3 protein, humanFatty Acid Binding Protein 3benign thyroid nodulebiomarkerclassificationDNA methylationFABP3thyroid cancer

Identifiers

PMID41019337
PMCPMC12462056

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.