ArticleInternational journal of cardiology. Cardiovascular risk and prevention2025
Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population.
Article in International journal of cardiology. Cardiovascular risk and prevention, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Box breathing and prolonged exhalation reduces markers of physiological stress reactivity in response to a virtual trier social stress test.Comprehensive psychoneuroendocrinology · 2026Article
- Networks and clusters of immunometabolic biomarkers and depression-associated features in middle-aged and older community-dwelling US adults with and without depression.Brain, behavior, & immunity - health · 2025Article
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Abstract
Introduction: Chronic emotional stress is a well-recognized risk factor for psychiatric and cardiometabolic disorders. The mediating role of low-grade inflammation in older, ethnically diverse populations has never been studied. Methods: The multiethnic ≥50-year-old study population is a subset of the Health and Aging Brain Study: Health Disparities (HABS-HD) study. Adjusted logistic and linear regression were used to assess associations. Statistical mediation analysis with non-parametric bootstrapping of confidence intervals was used to determine the intermediate role of Interleukin-6 (IL-6). Results: The study included 2173 participants (50-92 years). Black participants disclosed higher chronic stress levels than White and Hispanic participants. Having a chronic stress total score ≥ six points is associated with 53 % higher odds of disclosing concomitant cardiovascular disease (CVD) (adj.OR = 1.53 [1.10-2.53]), 31 % of Type-2 diabetes (T Conclusions: The study highlights a further aspect of the pathophysiological mechanisms involved in the brain-body communication. While IL-6 partially explains statistical associations between chronic emotional stress and major cardiometabolic disorders, no causal effects can be inferred from this study owing to the cross-sectional design. Larger longitudinal studies are needed to better clarify the temporal relationship between the events and to build upon our findings.
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