ArticleFrontiers in nutrition2025
Differential effects of prophylactic iron supplementation on physiological gestational anemia and post-IDA gestational anemia: a study based on a rat model.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To observe the effects of iron supplementation on a physiological pregnancy and on pregnancy following iron deficiency anemia (IDA) caused by low-iron diet. Method: Physiological pregnancy anemia and IDA-induced pregnancy rat models were established, and the effects of preventive iron supplementation with ferrous succinate tablets (Sulifei, SLF) and polysaccharide-iron complex (Niferex, LFN) on pregnancy ability, embryonic development, anemia indicators, and iron content and metabolic indicators were observed in the model rats. Result: Anemia markers and body iron content were decreased in physiological pregnancy rat model, accompanied by abnormal oxidative stress and iron metabolism. In post-IDA gestational rat model, these markers were even more severely aggravated. SLF and LFN intervention improved body iron content, oxidative stress, and iron metabolism-related markers in physiological pregnant rats, but did not improve anemia-related markers. After 6 weeks of pretreatment with SLF and LFN, some reproductive toxicity effects were observed. SLF and LFN intervention in post-IDA gestational rat model improved anemia markers, body iron content, and iron metabolism-related markers. There were no significant differences in reproductive parameters between the two groups. Fetal weight and the average crown-rump length per litter increased in the LFN group. Conclusion: Post-IDA gestation further exacerbates iron deficiency anemia. Prophylactic iron supplementation can significantly improve physiological iron deficiency and iron metabolism during pregnancy but cannot improve iron deficiency anemia. In contrast, iron supplementation can significantly improve iron deficiency anemia in post-IDA gestation. To prevent or treat pregnancy complicated by IDA, iron supplementation is recommended either before the onset of IDA or after pregnancy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.