ArticleFrontiers in nutrition2025
Association between magnesium depletion score and prevalence and all-cause mortality of psoriasis among the US population.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Magnesium plays a key role in the physiopathologic process of psoriasis. The recently proposed magnesium depletion score (MDS) represents a comprehensive index for assessing magnesium status. However, the effect of MDS on psoriasis remains to be elucidated. This study aimed to evaluate the possible association between MDS and psoriasis prevalence and mortality. Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) of adult participants. The multivariable logistic regression analysis was employed to assess the relationship between MDS and psoriasis prevalence. Restricted cubic splines (RCS) were utilized to investigate the dose-response correlation. Furthermore, Cox regression analysis was performed to determine the relationship between MDS and all-cause mortality in psoriasis patients. Furthermore, we conducted subgroup and sensitivity analyses to verify the validity and consistency of these results. Results: This study enrolled 17,883 eligible participants. After excluding individuals without follow-up information, 64 all-cause deaths were observed among 505 patients with psoriasis. In the weighted multivariable logistic regression model, individuals with an MDS ≥ 3 had a 1.75-fold greater risk of psoriasis compared with those with an MDS of 0 (OR = 1.75; 95% CI: 1.05-2.92; Conclusion: MDS is associated with an increased prevalence and all-cause mortality from psoriasis among American adults. Early detection and management for MDS may reduce the risk of psoriasis and improving its prognosis.
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