A spatial covariance

Judith R Harrison, Sean J Colloby, John T O'Brien, John-Paul Taylor

Abstract read

In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Judith R Harrison *Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, NE4 5PL, UK. judith.harrison@newcastle.ac.uk.ORCID http://orcid.org/0000-0002-5775-2524

Sean J Colloby *Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, NE4 5PL, UK.

John T O'BrienDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Level E4, Box 189, Cambridge, CB2 0QC, UK.

John-Paul TaylorTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, NE4 5PL, UK.

Funding

Medical Research Council G9817682

6 · The paper itself

Abstract

backgroundCholinergic dysfunction, particularly involving nicotinic acetylcholine receptors (nAChRs), contributes to cognitive and psychiatric symptoms in dementia with Lewy bodies (DLB), yet spatial covariance patterns remain unexplored. We aimed to characterise these patterns using

methodsFifteen DLB and 16 healthy controls underwent

resultsA distinct α4β2 nAChR pattern differentiated DLB from controls (F

conclusionThese findings provide novel insights into the pathophysiology of DLB and may inform future therapeutic strategies targeting nAChRs.

Indexed as

AzetidinesBrainLewy Body DiseasePyridinesReceptors, NicotinicTomography, Emission-Computed, Single-PhotonAgedAged, 80 and overFemaleHumansMaleMiddle AgedTechnetium Tc 99m Exametazime5-iodo-3-(2-azetidinylmethoxy)pyridineAzetidinesnicotinic receptor alpha4beta2PyridinesReceptors, NicotinicTechnetium Tc 99m ExametazimeAcetylcholineCholinergicDementia with Lewy bodiesNicotinicSpatial covarianceSPECT

Identifiers

PMID41021047

DOI10.1007/s00415-025-13332-5

PMCPMC12479619

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.