SynthesisBiogerontology2025
The impact of physical exercise on genotoxicity in older adults: a systematic review.
Synthesis in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
In the context of increasing life expectancy, a higher prevalence of age-related chronic diseases is becoming more common in the health landscape, many of which are closely linked to insufficient physical exercise during lifespan. On the other hand, aging is also associated with damage to various molecules, including DNA, by reactive oxygen species. Given that both senescence and muscle mass loss are intimately linked to increased levels of DNA damage and deterioration of antioxidant defense, this systematic review aims to evaluate whether regular physical exercise could indeed induce genotoxicity and to assess the quality of published articles on this topic. To achieve this objective, a total of 16 selected studies were meticulously analyzed by three experienced reviewers, who assigned scores to each study based on predetermined analysis parameters. Our results revealed that there is no consensus in the literature regarding genotoxicity induced by regular physical activity in older adults, regardless of the type, volume and intensity of exercise performed. In terms of quality assessment, 11 studies (out of 16) were categorized as Strong or Moderate, thus we consider our findings to be reliable. Undoubtedly, these findings are crucial for elucidating the role of regular physical exercise on genotoxicity-related biomarkers in older adults.
Indexed as
Identifiers
41021089What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.