Evidence map›Paper›PMID 41022751›Full record

ArticleNature communications2025

Maternal aggression driven by the transient mobilisation of a dormant hormone-sensitive circuit.

Stefanos Stagkourakis, Paul Williams, Giada Spigolon, Shreya Khanal, Katharina Ziegler, Laura Heikkinen, Gilberto Fisone, Christian Broberger

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Neural circuits for mammalian parental behaviour.Nature reviews. Neuroscience · 2026
    Review
  2. Article
  3. Review
  4. The hormonal and neural control of maternal aggression.Current opinion in neurobiology · 2026
    Review
  5. Article
  6. The neural control of infanticide and parental behaviors in male mice.bioRxiv : the preprint server for biology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Nutritionally Responsive PMv DAT Neurons Are Dynamically Regulated During Pubertal Transition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  11. CART Neurons in the Hypothalamic Ventral Premammillary Nucleus (PMv) in Rats Mediate Maternal, But Not Inter-male Aggression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Stefanos StagkourakisSciLifeLab, Department of Neuroscience, Karolinska Institutet, Solna, Sweden. stefanos.stagkourakis@scilifelab.se.ORCID http://orcid.org/0000-0003-1218-791X
Paul WilliamsDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Giada SpigolonSciLifeLab, Department of Neuroscience, Karolinska Institutet, Solna, Sweden.
Shreya KhanalSciLifeLab, Department of Neuroscience, Karolinska Institutet, Solna, Sweden.
Katharina ZieglerSciLifeLab, Department of Neuroscience, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0003-2111-8916
Laura HeikkinenSciLifeLab, Department of Neuroscience, Karolinska Institutet, Solna, Sweden.
Gilberto FisoneSciLifeLab, Department of Neuroscience, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0002-0719-8000
Christian BrobergerSciLifeLab, Department of Neuroscience, Karolinska Institutet, Solna, Sweden. christian.broberger@dbb.su.se.ORCID http://orcid.org/0000-0002-7050-8809

Funding

Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) 2020.0054
6 · The paper itself

Abstract

Aggression is a sexually dimorphic behaviour. In some species, including the laboratory mouse, it is robustly expressed in males - while females are not aggressive in the non-puerperal state. However, during nursing, females exhibit maternal aggression, a dramatic yet transient shift in their social behaviour repertoire. This phenotypic change occurring in adulthood presents an opportunity to investigate whether sex-biased behavioural programs depend on mono- or di-morphic neural circuits. While maternal hormones are known to elicit nursing, their role in maternal aggression, particularly regarding target sites and cellular mechanisms, remains unclear. Here, we show that a molecularly defined subset of mouse ventral premammillary (PMv

Indexed as

AggressionMaternal BehaviorNeuronsOxytocinProlactinAnimalsBehavior, AnimalFemaleLactationMaleMiceMice, Inbred C57BLSocial BehaviorOxytocinProlactin

Identifiers

PMID41022751
PMCPMC12480473

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.