Evidence map›Paper›PMID 41023229›Full record

ArticleAesthetic plastic surgery2025

Tarantula Cubensis Venom Theranekron-Embedded Hyaluronic Acid and Chitosan-Based Wound Dress Enhances Wound Healing by Ameliorating Histopathological Appearance and Enhancing Growth Factors in Low Doses: In Vitro and In Vivo Study.

Rumeysa Taner, Halil Asci, Sule Sultan Ugur, Mehtap Savran, Muhammet Yusuf Tepebasi, Ozlem Ozmen

Abstract read
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Article in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rumeysa TanerDepartment of Bioengineering, Institute of Science, Suleyman Demirel University, 32260, Isparta, Türkiye. rrumeysataner@gmail.com.ORCID 0000-0002-2845-3744
Halil AsciDepartment of Bioengineering, Institute of Science, Suleyman Demirel University, 32260, Isparta, Türkiye.
Sule Sultan UgurDepartment of Bioengineering, Institute of Science, Suleyman Demirel University, 32260, Isparta, Türkiye.
Mehtap SavranDepartment of Bioengineering, Institute of Science, Suleyman Demirel University, 32260, Isparta, Türkiye.
Muhammet Yusuf TepebasiDepartment of Medical Genetics, Suleyman Demirel University, 32260, Isparta, Türkiye.
Ozlem OzmenDepartment of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, 15030, Burdur, Türkiye.

Funding

Süleyman Demirel Üniversitesi FYL-2023-9021
6 · The paper itself

Abstract

backgroundThis study aimed to produce wound dressing materials using the multilayer coating method(LbL) with varying doses of theranekron®(T) incorporated into hyaluronic acid (HA)/chitosan(Ch) multilayer films, demonstrating their proliferative effect through in vivo wound model experiments. MATERIAL AND

methodsIn vitro wound dressings were created by dipping 2 × 2 cm cotton fabrics into T solutions via the LbL method. Four circular wounds (1.5 cm diameter) were made on the dorsal area of 16 rats. Eight groups (control, HA-Ch, T

resultsSEM-EDS analysis of treated cotton fabric indicated compositions of 44.79% carbon, 48.56% oxygen, 6.19% nitrogen, and 0.46% calcium. Ch particles were evenly distributed on HA-Ch-coated fibers; however, crystalline structures diminished with increasing doses. Wound healing rates significantly increased in the T

conclusionThe study confirmed the in vivo and in vitro efficacy of the T + HA + Ch wound dressing material, identifying the optimal wound healing dose of T as 10-50 µg based on histopathological and genetic analyses. NO LEVEL ASSIGNED: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Indexed as

BandagesChitosanHyaluronic AcidWound HealingAnimalsDisease Models, AnimalDose-Response Relationship, DrugIntercellular Signaling Peptides and ProteinsIn Vitro TechniquesMaleRatsRats, Sprague-DawleyRats, WistarChitosanHyaluronic AcidIntercellular Signaling Peptides and ProteinsChitosanEpidermal growth factorHyaluronic acidLayer-by-layer nanoparticlesSpider venomsTarantula cubensisWound healing

Identifiers

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.