Evidence map›Paper›PMID 41023281›Full record

ArticleScientific reports2025

Association between CYP17A1 and HSD3B1 gene polymorphisms and testosterone levels in Nigerian prostate cancer patients.

Christogonus Chichebe Ekenwaneze, Suleiman Zakari, Emmanuel Chimuebuka Amadi, Mary Okesola, Solomon Oladapo Rotimi, Ademola Oyekan, Olamijulo Fatiregun, Emeka Eze Joshua Iweala, Folakemi Odedina, Olubanke Olujoke Ogunlana

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christogonus Chichebe EkenwanezeDepartment of Biochemistry, College of Science and Technology, Covenant University, KM. 10 Idiroko Road, Canaan Land, Ota, 112104, Ogun State, Nigeria. christogonus.ekenwanezepgs@stu.cu.edu.ng.
Suleiman ZakariDepartment of Biochemistry, College of Science and Technology, Covenant University, KM. 10 Idiroko Road, Canaan Land, Ota, 112104, Ogun State, Nigeria.
Emmanuel Chimuebuka AmadiDepartment of Biochemistry, College of Science and Technology, Covenant University, KM. 10 Idiroko Road, Canaan Land, Ota, 112104, Ogun State, Nigeria.
Mary OkesolaDepartment of Biochemistry, College of Science and Technology, Covenant University, KM. 10 Idiroko Road, Canaan Land, Ota, 112104, Ogun State, Nigeria.
Solomon Oladapo RotimiDepartment of Biochemistry, College of Science and Technology, Covenant University, KM. 10 Idiroko Road, Canaan Land, Ota, 112104, Ogun State, Nigeria.
Ademola OyekanLagos State University Teaching Hospital (LASUTH), Ikeja, Lagos State, Nigeria.
Olamijulo FatiregunLagos University Teaching Hospital (LUTH), Surulere, Lagos State, Nigeria.
Emeka Eze Joshua IwealaDepartment of Biochemistry, College of Science and Technology, Covenant University, KM. 10 Idiroko Road, Canaan Land, Ota, 112104, Ogun State, Nigeria.
Folakemi OdedinaCommunity Outreach and Engagement Office and Programs, Mayo Clinic Comprehensive Cancer Centre, 4500 San Pablo Road, Jacksonville, FL, 3224, USA.
Olubanke Olujoke OgunlanaDepartment of Biochemistry, College of Science and Technology, Covenant University, KM. 10 Idiroko Road, Canaan Land, Ota, 112104, Ogun State, Nigeria. banke.ogunlana@covenantuniversity.edu.ng.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PCa) is a primary global health concern and the leading cause of cancer-related deaths in men. Genetic variation in androgen pathways is essential in PCa development and progression. Cytochrome P450 17A1 (CYP17A1) gene encodes a critical metabolic enzyme involved in testosterone (TT) synthesis, as it converts cholesterol into androstenedione. Similarly, the 3β-hydroxysteroid dehydrogenase type 1 (HSD3B1) gene encodes an enzyme that catalyses the conversion of dehydroepiandrosterone (DHEA) to androstenedione, a critical precursor for TT production. The case-control study was conducted on 40 PCa patients and 40 healthy males with matching ages. Detection of CYP17A1 and HSD3B1 polymorphisms was done using the TaqMan genotyping assay, and estimation of TT levels in serum was done using the enzyme-linked immunosorbent assay technique. Detected genotypes were AA, AG, and GG for CYP17A1, and AA and CA for HSD3B1; the adrenal-permissive CC genotype of HSD3B1 was absent. The TT levels were significantly lower in PCa patients (p = 0.00148). No significant associations were found between polymorphisms in CYP17A1, HSD3B1 and TT levels. The HSD3B1 CA genotype showed a non-significant trend toward increased PCa risk (OR = 2.39, p = 0.183) that requires validation in larger studies before any clinical relevance can be established.

Indexed as

Multienzyme ComplexesPolymorphism, Single NucleotideProgesterone ReductaseProstatic NeoplasmsSteroid 17-alpha-HydroxylaseSteroid IsomerasesTestosteroneAgedCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle Aged3 beta-hydroxysteroid oxidoreductase-delta(5) 3-ketosteroid isomeraseCYP17A1 protein, humanMultienzyme ComplexesProgesterone ReductaseSteroid 17-alpha-HydroxylaseSteroid IsomerasesTestosteroneAndrogen metabolismHormonal regulationMolecular biomarkerProstate cancer riskSingle nucleotide polymorphism

Identifiers

PMID41023281
PMCPMC12480943

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.