ReviewMolecular biology reports2025
The effects of incretins as a double-edged sword on cancer.
Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Deciphering mitochondrial metabolic vulnerabilities in ovarian clear cell carcinoma with mass spectrometry-based clinical proteomics.Expert review of proteomicsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIncretins, such as Glucagon-like peptide-1 (GLP-1) and Glucose-dependent insulinotropic peptide (GIP), are hormones known to stimulate insulin secretion and are widely used in the management of type 2 diabetes mellitus (T2DM). Recent evidence suggests that these hormones, and incretin-based therapies like DPP-4 inhibitors and GLP-1 receptor agonists, may have proliferative effects on pancreatic β-cells, raising concerns about a potential link to certain cancers. This review aims to evaluate both the beneficial and detrimental effects of incretins in cancer development and therapy.
methodsWe conducted a comprehensive review of clinical cohort studies, as well as in vivo and in vitro investigations, to assess the dual role of incretin-based therapies in cancer risk and potential treatment. The molecular and cellular mechanisms underlying these effects were critically analyzed.
resultsWhile some studies have suggested an increased risk of pancreatic, thyroid, cholangiocarcinoma, and colorectal cancers associated with incretin therapies-especially in genetically predisposed individuals-other research has demonstrated anticancer effects in prostate, breast, ovarian, and other cancers through various mechanisms. These include inhibition of tumor proliferation, induction of apoptosis, and modulation of immune responses.
conclusionAlthough incretin-based drugs may pose a cancer risk in specific tissues, particularly in susceptible individuals, their therapeutic potential in mitigating other cancer types appears promising. The overall evidence suggests that the benefits of incretins may outweigh the risks when patient-specific factors are carefully considered.
Indexed as
Identifiers
41023473What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.