ReviewMolecular medicine (Cambridge, Mass.)2025
Genomic medicine in hepatology: mechanisms and liver treatment strategies.
Review in Molecular medicine (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular and Regenerative Effects of Platelet-Rich Plasma and Related Hemocomponents in Animal Models of Liver Injury-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Gene therapy for liver diseases: methods, challenges and opportunities.Journal of nanobiotechnology · 2026Review
- α-Hederin Alleviates Endoplasmic Reticulum Stress by Upregulating TRIM38 Expression, Thereby Inhibiting Hepatic Stellate Cell Activation and Liver Fibrosis.Biomedicines · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Chronic liver diseases are a rapidly growing threat to global health, causing approximately 2 million deaths annually—half from complications of cirrhosis and half from viral hepatitis and hepatocellular carcinoma. Despite this, effective diagnostic and therapeutic options remain limited, prompting an urgent need for novel translational strategies. Gene-based therapeutics have emerged as a promising solution compared to conventional treatments. This review highlights the therapeutic potential of delivering nucleic acid drugs using nanoengineered materials, which take advantage of the liver’s unique anatomical and physiological characteristics. We overview the liver physiology and function, and the underlying mechanisms of gene therapy—including gene augmentation, gene silencing, and gene editing. Special attention is given to current strategies and mechanisms of gene therapy. Furthermore, we discuss the clinical translation, benefits, and limitations of gene-based approaches in treating the most widespread liver diseases and pathologies such as nonalcoholic fatty liver disease, hepatic inflammation, hepatitis, and fibrosis. By addressing the current challenges and opportunities, this review underscores the transformative potential of nanoengineered gene therapeutics in advancing liver disease treatment and shaping the future of precision hepatology.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.