Evidence map›Paper›PMID 41023707›Full record

ReviewEuropean journal of medical research2025

Role of long non-coding RNAs in cartilage development and osteoarthritis pathogenesis.

Xuejiao Sun, Shan Wang, Jun Tian, Mingxing Li

Abstract readReview
In one paragraph

Review in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xuejiao SunDepartment of Rehabilitation Medicine, Zhongnan Hospital, Wuhan University, No.169 Donghu Road, Wuhan, 430071, China.
Shan WangDepartment of Rehabilitation Medicine, Zhongnan Hospital, Wuhan University, No.169 Donghu Road, Wuhan, 430071, China.
Jun TianDepartment of Rehabilitation Medicine, Zhongnan Hospital, Wuhan University, No.169 Donghu Road, Wuhan, 430071, China. tianjun@znhospital.cn.
Mingxing LiAffiliated Wuhan Mental Health Center, Tongji Medical College, Huazhong University of Science and Technology, No.89 Gonglongbing Road, Wuhan, 430012, China. china123li@aliyun.com.

Funding

the Natural Science Foundation of Hubei Province of China 2023AFB199the Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund CXPY2020018
6 · The paper itself

Abstract

Osteoarthritis (OA) is a progressive joint disease characterized by the degradation of cartilage, remodeling of subchondral bone, and inflammation of synovial tissue, posing growing global health challenges. Long non-coding RNAs (lncRNAs) play crucial roles in various physiological and pathological processes associated with OA, including extracellular matrix (ECM) degradation, synovial inflammation, chondrocyte apoptosis, and angiogenesis. Chondrogenesis involves mesenchymal cell condensation followed by differentiation into chondrocytes, hypertrophy of chondrocytes, and subsequent maturation. This review aims to provide an updated overview of lncRNAs and their involvement in cartilage development as well as OA. Furthermore, we discuss the potential utility of lncRNAs as molecular biomarkers for early diagnosis and treatment of OA.

Indexed as

Cartilage, ArticularGene Expression Regulation, DevelopmentalOsteoarthritisRNA, Long NoncodingAnimalsBiomarkersCell DifferentiationChondrocytesChondrogenesisHumansSynovial MembraneBiomarkersRNA, Long NoncodingBiomarkersCartilage developmentLncRNAOsteoarthritisPathogenesis

Identifiers

PMID41023707
PMCPMC12482591

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.