ArticleBMC oral health2025
Dental and oral symptoms and the risk of incident systemic lupus erythematosus: a prospective study of 438,555 UK biobank participants.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Denture use is associated with a higher risk of cholelithiasis: a prospective cohort study.BMC oral health · 2026Article
- Oral and cardiometabolic health through the lens of biobanks and large-scale epidemiologic research.Frontiers in oral health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectivesTo investigate whether common dental and oral symptoms are associated with an increased risk of systemic lupus erythematosus (SLE).
methodsParticipants initially free of SLE from the UK Biobank were included. Five prevalent dental and oral symptoms, namely, mouth ulcers, painful gums, bleeding gums, toothache, and loose or lost teeth or dentures, were ascertained from touchscreen questionnaires at baseline. The symptoms found to be associated with an increased risk of SLE were summed to evaluate the association of cumulative symptoms with SLE onset. Cox proportional hazard models were used to estimate the hazard ratio (HR) and 95% confidence interval (95% CI). Subgroup analyses were conducted to identify potential effect modifiers.
resultsA total of 438,555 participants (mean age 56.2 years, 53.8% female) were included. During a median follow-up Duration of 11.76 years, 350 SLE cases were reported. The HRs (95% CIs) of incident SLE for five individual dental and oral symptoms, mouth ulcers, painful gums, bleeding gums, loose or lost teeth or dentures, toothache were 1.44 (1.04-1.98), 1.62 (1.01-2.58), 1.08 (0.78-1.48), 1.40 (1.08-1.81), and 0.99 (0.5-1.67), respectively. The HRs of the risk of SLE for participants with one, two, or three significant symptoms (including mouth ulcers, painful gums, and loose or lost teeth) were 1.30 (1.03-1.64), 1.78 (1.13-2.80), and 3.29 (1.35-8.02), respectively. A greater risk was observed in the female subgroup.
conclusionsMouth ulcers, painful gums and loose or lost teeth were associated with an increased risk of SLE. Moreover, an increased number of oral health symptoms was associated with a greater risk of SLE onset.
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Registered trials
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