ArticleJournal of nanobiotechnology2025
Lactobacillus johnsonii-derived extracellular vesicles restore mucosal immunity via taurine-linked Th17/Treg and IgA/IgG regulation in colitis.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Microbiota-Associated Amino Acid Metabolites in Inflammatory Bowel Disease: Emerging Key Players in the Host-Microbe Interface.Microorganisms · 2026Review
- Bacterial Extracellular Vesicles at the Crossroads of Immune Regulation and Biofilm Dynamics: Biogenesis, Comparative Analysis, and Translational Challenges.Biomolecules · 2026Review
- Identification and Characterization ofMicroorganisms · 2026Article
- Anti-aging potential of Limosilactobacillus fermentum F-B9-1-2 extracellular vesicles in D-galactose-induced cellular and organ senescence.Scientific reports · 2026Article
- Article
- Strain-resolved biology ofFrontiers in veterinary science · 2026Review
- Probiotic-Derived Extracellular Vesicles as Potential Nano-Immunotherapeutic Platforms in IBD: A Clinician's Perspective.International journal of nanomedicine · 2026Review
- Gut microbiota-immune crosstalk in osteoarthritis: pathogenic mechanisms and emerging therapeutic opportunities.Frontiers in microbiology · 2026Review
- Exosomes in Inflammatory Bowel Disease: Mechanisms, Diagnostic Potential, and Engineering Strategies for Precision Therapy.International journal of medical sciences · 2026Review
- Associations between rivaroxaban dose, gut microbiota, and coagulation parameters in a rat model.Thrombosis journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundAberrant mucosal immune responses to gut microbiota contribute to inflammatory bowel disease (IBD), yet the mechanisms linking immunoglobulin-coated bacteria to mucosal inflammation remain unclear. Microbial extracellular vesicles (EVs) have emerged as potential modulators of host–microbiota interactions, metabolism, and immunity. This study examined how Lactobacillus johnsonii-derived EVs influence gut microbiota, amino acid metabolism, mucosal T cell polarization—particularly the Th17/Treg balance—and immunoglobulin transport in experimental colitis.
resultsFlow cytometry of fecal samples from IBD patients revealed increased IgA-, IgG-, and IgM-coated bacteria. Colonic expression of PIGR and FcRn was also elevated. L. johnsonii was depleted in ulcerative colitis, whereas Proteobacteria and Escherichia_Shigella were enriched. EVs displayed high structural integrity, gastrointestinal stability, and enhanced accumulation in inflamed colon. In DSS-induced colitis mice, both L. johnsonii and EVs alleviated inflammation, improved histology, reduced pro-inflammatory cytokines, decreased Th17 cells, increased Treg cells, and restored the Th17/Treg balance. These interventions also reduced IgA-, IgG-, and IgM-coated bacteria, lowered fecal immunoglobulins without affecting systemic levels, and downregulated PIGR and FcRn. Multi-omics analyses showed that EVs reshaped gut microbiota, enriched taurine-associated taxa (Lactobacillales, Lactobacillaceae, Lactobacillus murinus), and elevated the immunoregulatory metabolite taurine, which was linked to sulfur metabolism and epithelial homeostasis. Taurine supplementation reproduced EV effects, including reduced inflammation, improved barrier integrity, Th17/Treg rebalancing, and suppression of PIGR and FcRn.
conclusionsL. johnsonii-derived EVs restore mucosal immune balance in colitis through a coordinated EV–taurine–Th17/Treg–PIGR/FcRn–IgA/IgG axis. By integrating microbiota remodeling, metabolic regulation, and immune modulation—and outperforming the parent bacterium in stability, colonic enrichment, and breadth of effect—these EVs represent promising next-generation biologics for IBD therapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.