ArticleLipids in health and disease2025
Obesity alters VLDL profile and remnant cholesterol differently in metabolically healthy men and women: a ¹H-NMR study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
BACKGROUND AND
aimsLipoprotein particle (p) size and count beyond lipoprotein lipid content [triglycerides (tg) and cholesterol (c)] are critical for their atherogenicity. This study characterized lipoprotein profiles in metabolically healthy individuals with overweight or obesity and assessed the impact of sex, obesity, and lipid background.
methodsProton-nuclear magnetic resonance (¹H-NMR) was used to assess the composition of very low-, low-, intermediate-, and high-density lipoproteins (VLDL, LDL, IDL, HDL), and particle number and size of VLDL, LDL, and HDL in 101 healthy subjects with overweight and obesity.
resultsMen showed significantly higher VLDLc and VLDLtg levels, counts of VLDLp (all subfractions) and LDLp (total and small), and smaller LDLp size, compared to women. Men had lower HDLc and HDLp (total and medium). In Obesity (Ob) compared to overweight (Ov), VLDLp number, VLDLtg and remnant cholesterol (RC) levels were significantly increased [Fold changes (FC) Ob.vs.Ov: 1.45, 1.39, and 1.26, respectively]. When stratified by sex, obesity-related VLDL and IDL profile deterioration was evident only in women. Individuals with LDLc ≥ 130 mg/dL showed increased RC compared to those with LDLc < 130 mg/dL (FC:1.26). The median 10-year cardiovascular disease (CVD) risk REGICOR was low (2%), but higher in men and in obesity. Individuals with higher CVD risk showed increased VLDLc, VLDLtg, VLDLp, and RC levels.
conclusionMen had a higher 10-year CVD risk and a less favorable triglyceride-rich lipoprotein and RC profile, while obesity aggravated these patterns, particularly in women. These findings support considering high-risk lipoprotein patterns in targeted CVD prevention for overweight and obese populations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.