ArticleWorld journal of gastrointestinal surgery2025
Effects of stellate ganglion block anesthesia on cognition and biomarkers in patients undergoing gastrointestinal surgery.
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSurgery is a common treatment for gastrointestinal tumors. General anesthesia (GA), while effective, can cause oxidative stress reactions and neuroinflammation, potentially leading to postoperative cognitive dysfunction and gastrointestinal dysfunction. The stellate ganglion block (SGB) can reduce sympathetic excitability and stress responses. This study aims to investigate whether combining SGB with GA can mitigate these adverse effects in patients undergoing gastrointestinal surgery.
aimTo analyze the effects of SGB plus GA on hemodynamic stability, oxidative stress, neuroinflammation, cognitive function, and gastrointestinal function in patients undergoing gastrointestinal surgery.
methodsPatients undergoing gastrointestinal surgery between October 2022 and December 2024 were divided into two groups: A single GA group and an SGB combined with GA group (40 patients each). Hemodynamics, oxidative stress response, laboratory indices, cognitive function, and gastrointestinal function were compared preoperatively and 24 hours postoperatively between the two groups. Pain levels and complications were also recorded.
resultsBefore anesthesia induction, no significant differences were found in various indexes (including hemodynamics, oxidative stress indicators, laboratory indices, cognitive function scores, and gastrointestinal function indicators) between the two groups (
conclusionCombining SGB with GA can maintain perioperative hemodynamic stability, reduce oxidative stress and neuroinflammatory injury, and attenuate postoperative cognitive decline and gastrointestinal dysfunction in patients undergoing gastrointestinal surgery.
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