Evidence mapPaperPMID 41024968Full record

ArticleWorld journal of cardiology2025

Fractional flow reserve guided percutaneous coronary intervention

Suhas Kataveni, Ezza Ellahi, Fabeha Zafar, Ihsan Noushad Karuppan Veettil, Amna Iqbal, Bhavya Dhir, Shivani Sabarish, Sai Erambalur, Meenakshi Reddy Yathindra, Moukthika Kvn and 5 more

Abstract read
In one paragraph

Article in World journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Suhas KataveniDepartment of Cardiology, Gandhi Medical College, Hyderabad 500001, Telangana, India.
Ezza EllahiDepartment of Cardiology, Aziz Fatimah Hospital, Faisalabad 37000, Punjab, Pakistan.
Fabeha ZafarDepartment of Cardiology, Dow University of Health Sciences, Karachi 75280, Sindh, Pakistan.
Ihsan Noushad Karuppan VeettilDepartment of Cardiology, Sree Narayana Medical College, Ernakulam 683594, Kerala, India.
Amna IqbalDepartment of Cardiology, Wah Medical College, Islamabad 47010, Islamabad, Pakistan.
Bhavya DhirDepartment of Cardiology, Government Medical College, Patiala 147001, Punjab, India.
Shivani SabarishDepartment of Cardiology, Gandhi Medical College, Hyderabad 500001, Telangana, India.
Sai ErambalurDepartment of Cardiology, Richmond Gabriel University, St. Vincent and Grenadines VCO130, Saint Vincent and the Grenadines.
Meenakshi Reddy YathindraDepartment of Cardiology, Kasturba Medical College, Mangalore 575001, Karnataka, India.
Moukthika KvnDepartment of Cardiology, Sri Venkateshwara Institute of Medical Sciences, Tirupati 517501, Andhra Pradesh, India.
Shayan NawazDepartment of Cardiology, University College of Medicine & Dentistry, Lahore 54000, Punjab, Pakistan.
Satish Kumar DudekulaDepartment of Cardiology, University of Perpetual Help System Dalta, Las Piñas CPO 1740, Metro Manila, Philippines.
Usman Ul HaqDepartment of Medicine, Medway Maritime Hospital NHS Foundation Trust, Gillingham ME7 5NY, United Kingdom.
Asraf HussainDepartment of Cardiology, Chitwan Medical College, Bharatpur 33915, Nepal. drasrafcardiology@gmail.com.
Muhammad Muneeb KhawarDepartment of Cardiology, King Edward Medical University, Lahore 05450, Punjab, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) are well-established treatments for multivessel coronary artery disease (CAD), a condition where multiple heart arteries are narrowed. A newer approach, fractional flow reserve (FFR)-guided PCI, uses a specialized measurement to select which artery blockages to treat, aiming to enhance patient outcomes. Despite its adoption, the comparative effectiveness of FFR-guided PCI

aimTo evaluate the safety and effectiveness of FFR -guided PCI compared to CABG in patients with multivessel CAD.

methodsThis meta-analysis followed standard reporting guidelines and included randomized controlled trials (RCTs) comparing FFR-guided PCI with CABG in patients with multivessel CAD. We searched medical databases, including PubMed, EMBASE, ScienceDirect, and ClinicalTrials.gov, from their start to May 2025. We calculated combined risk ratios (RRs) with 95% confidence intervals (95%CIs) to analyze the data.

resultsThree RCTs were analyzed. There was no notable difference in all-cause mortality between FFR-guided PCI and CABG (RR = 1.01, 95%CI: 0.78-1.31,

conclusionFFR-guided PCI and CABG have similar rates of all-cause mortality and stroke in patients with multivessel CAD. However, CABG results in fewer MACEs, myocardial infarctions, and repeat procedures.

Indexed as

Coronary artery bypass graftingFractional flow reserveMeta-analysisMultivessel coronary artery diseasePercutaneous coronary intervention

Identifiers

PMID41024968
PMCPMC12476596

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.