Evidence map›Paper›PMID 41026363›Full record

ArticleInternational urology and nephrology2026

Low-intensity energy shock wave therapy modulates bladder function and anxiety-like behavior in maternal separation rats.

Tadanobu Chuyo Kamijo, Masahiro Kurobe, Takahiro Akimoto, Minoru Miyazato

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Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Tadanobu Chuyo KamijoDepartment of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, 1046 Kiyuna, Ginowan, Okinawa, 903-0215, Japan.
Masahiro KurobeDepartment of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, 1046 Kiyuna, Ginowan, Okinawa, 903-0215, Japan.
Takahiro AkimotoDepartment of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, 1046 Kiyuna, Ginowan, Okinawa, 903-0215, Japan.
Minoru MiyazatoDepartment of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, 1046 Kiyuna, Ginowan, Okinawa, 903-0215, Japan. miyaz929@cs.u-ryukyu.ac.jp.ORCID http://orcid.org/0000-0003-3669-4510

Funding

Japan Society for the Promotion of Science 23K10504
6 · The paper itself

Abstract

aimsTo investigate whether low-intensity energy shock wave therapy (LiESWT) applied to the bladder can alleviate maternal separation (MS)-induced lower urinary tract dysfunction and anxiety-like behavior in a rat model.

methodsSprague-Dawley rat pups were divided into normal, MS, and MS + LiESWT groups. MS was performed on postnatal days 2-14. At 6 weeks of age, the MS + LiESWT group received shock wave therapy (0.12 mJ/mm

resultsCompared to normal rats, MS rats exhibited increased bladder weight, shortened intercontraction intervals, and increased anxiety-like behavior. LiESWT treatment normalized bladder weight and improved urinary frequency compared to MS rats, and reduced anxiety-like behavior, as evidenced by recovery of time spent in the open arms of the elevated plus maze. Sex-related differences were observed, with effects being more pronounced in females. This was particularly evident in the voiding frequency during the dark phase and the adrenal gland weight.

conclusionsLiESWT applied to the bladder improved bladder dysfunction and reduced anxiety-like behavior in MS rats, suggesting potential interactions between bladder function and emotional state that may involve shared neural circuits. The findings indicated the potential therapeutic applications of LiESWT for improving the stress-induced dysfunction affecting the integrated neurobiological pathways that govern both bladder control and behavioral regulation.

Indexed as

AnxietyExtracorporeal Shockwave TherapyMaternal DeprivationUrinary BladderAnimalsBehavior, AnimalDisease Models, AnimalFemaleMaleRatsRats, Sprague-DawleyAnxietyBladder dysfunctionEarly-life stressLow-intensity energy shock wave therapyMaternal separationSex-related differences

Identifiers

PMID41026363

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.