ArticleScientific reports2025
Epigenetic aging acceleration among World Trade Center-exposed community members.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Evolving Cancer Characteristics Among World Trade Center Survivors: An Updated Analysis from the WTC Environmental Health Center.International journal of environmental research and public health · 2026Article
- Epigenetic Clocks, Resilience, and Multi-Omics Ageing: A Review and the EpiAge-R Conceptual Framework.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Aging is a complex biological process, and some individuals are aging faster or slower than expected. This phenomenon of aging acceleration occurs when biological age exceeds chronological age and can be assessed by epigenetic clock estimation. As aging acceleration is known to occur in response to some environmental exposures as well as trauma, we hypothesized that World Trade Center (WTC) exposures may have led to epigenetic aging acceleration. WTC-exposed women were selected from the World Trade Center Environmental Health Center (WTC EHC) clinic, with peripheral blood collected during routine clinical monitoring visits. The reference group was selected from the NYU Women's Health Study (NYUWHS), a prospective cohort study that collected blood samples before 9/11/2001. Epigenomes of WTC-exposed vs. unexposed women were profiled using the Infinium MethylationEPIC array. DNA-based epigenetic aging was estimated using Hannum, Horvath, PhenoAge and GrimAge epigenetic clocks. Age acceleration was defined as the residual from regressing estimated epigenetic age on chronological age. Ordinary least squares regression was used to investigate the relationship between WTC exposure and accelerated aging. After adjustment for race/ethnicity, smoking status, Body Mass Index (BMI), batch and cell type composition, WTC exposure was associated with epigenetic aging acceleration using the Hannum epigenetic clock (β
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.