ArticleCardiovascular engineering and technology2025
Validation of a Mathematical Model of Arterial Wall Mechanics with Drug Induced Vasoconstriction Against Ex Vivo Measurements.
Article in Cardiovascular engineering and technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
purposeIn this work we investigate a mathematical model in order to reproduce experimental data of arterial compliance under the action of vasoconstrictors and vasodilators related to pharmacological studies.
methodsThe considered model is a 3D-shell with active fibers. Model parameters are identified by means of an optimization procedure.
resultsThe resulting model was able to reproduce the experimental data and predict the system behavior in scenarios other than those used for the parameter estimation. This enables the assessment of different scenarios concerning the impact of the molecules on the active or passive contributions of the arterial wall.
conclusionThe results suggest that smooth muscle cell contraction modulates stiffness through direct fiber-induced regulation of vascular tone, while parameters related to the passive arterial wall component remain relatively stable across different vasoactive scenarios.
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