Evidence map›Paper›PMID 41029458›Full record

ReviewReproductive biology and endocrinology : RB&E2025

Hydrogen sulfide in placental development and pregnancy disorders: mechanisms, therapeutic potential, and translational challenges.

Lijia Du, Rui Zheng, Weina Ren, Yingru Liu, Xiaoxiong Zhu, Shiyang Chang, Zhifen Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reproductive biology and endocrinology : RB&E, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lijia Du *Obstetrical Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Rui Zheng *Obstetrical Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Weina RenObstetrical Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Yingru LiuObstetrical Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Xiaoxiong ZhuObstetrical Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Shiyang ChangDepartment of Histology and Embryology, College of Basic Medical, Hebei Medical University, Shijiazhuang, China. 18901410@hebmu.edu.cn.
Zhifen YangObstetrical Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. cxsxfy@126.com.

Funding

National Natural Science Foundation of China 32471044Natural Science Foundation of Hebei Province H2022206212the Government-Funded Program for Training Outstanding Clinical Medical Talents ZF2025212the Medical Science Research Project of Hebei 20230775the Medical Science Research Project of Hebei 20240817the Research and Innovation Team of the Fourth Hospital of Hebei Medical University 2023C04
6 · The paper itself

Abstract

The placenta plays a crucial role in maintaining pregnancy stability, regulating fetal growth, and facilitating maternal-fetal exchange. Its proper development relies on placental vasculogenesis and angiogenesis, along with adaptive remodeling of the maternal uterine vasculature. However, the mechanisms underlying placental development and the successful establishment of the maternal-fetal interface remain incompletely understood. As the third gaseous signaling molecule identified after nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H₂S) has been demonstrated to regulate vascular adaptation during pregnancy by promoting angiogenesis and neovascularization. Dysregulated H₂S biosynthesis has been implicated in pregnancy complications, including preeclampsia (PE), fetal growth restriction (FGR), and preterm birth (PTB), underscoring its potential as a therapeutic target. Recent studies have revealed that H₂S regulates placental function via multiple signaling pathways, including activating adenosine triphosphate (ATP)-sensitive K

Indexed as

Hydrogen SulfidePlacentaPlacentationPregnancy ComplicationsAnimalsFemaleHumansPregnancySignal TransductionTranslational Research, BiomedicalHydrogen SulfideEstradiol-βFetal growth restriction (FGR)H₂S donorsHydrogen sulfide (H2S)Placental developmentPreeclampsia (PE)Spiral artery remodeling (SAR)Uterine blood flow (UtBF)

Identifiers

PMID41029458
PMCPMC12486883

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.