Evidence map›Paper›PMID 41029625›Full record

ArticleBMC cancer2025

Exploring irisin levels in patients with endometrial atypical hyperplasia and carcinoma: a comparative analysis.

Tevfik Berk Bildacı, Can Ata, Ufuk Atlıhan, Huseyin Aytug Avsar, Selcuk Erkılınc

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tevfik Berk BildacıFaculty of Medicine, OB/GYN Department, Izmir Democracy University Buca Seyfi Demirsoy Training and Research Hospital, Izmir, Turkey. berkbildaci@gmail.com.
Can AtaFaculty of Medicine, OB/GYN Department, Izmir Democracy University Buca Seyfi Demirsoy Training and Research Hospital, Izmir, Turkey.
Ufuk AtlıhanPrivate Izmir Karatas Hospital OB/GYN Department, Izmir, Turkey.
Huseyin Aytug AvsarFaculty of Medicine, OB/GYN Department, Izmir Democracy University Buca Seyfi Demirsoy Training and Research Hospital, Izmir, Turkey.
Selcuk ErkılıncFaculty of Medicine, OB/GYN Department, Izmir Democracy University Buca Seyfi Demirsoy Training and Research Hospital, Izmir, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndometrial atypical hyperplasia (EAH) is recognized as the precursor to type I endometrial cancer. Endometrial cancer (EC), strongly associated with disorders in glucose metabolism such as obesity and insulin resistance, is believed to be influenced by hormones secreted from adipose tissue known as adipokines.

methodsIn a cross-sectional case-control study, 88 patients diagnosed with either EAH or EC were enrolled. Their irisin levels in serum were compared to those of a control group.

resultsIrisin levels were significantly higher in patients with both EAH and EC compared to the control group (p = 0.022). In multivariable analysis, the association between irisin and EAH remained statistically significant and independent after adjustment for covariates (p = 0.018), whereas the association with EC was weakened and did not remain statistically significant (p = 0.071).

conclusionWe demonstrated that Irisin levels in patients with EAH or EC differ from those in a control group, suggesting that irisin levels are correlated with the risks of EH and EC. Larger studies are required to clarify the potential use of irisin in the diagnosis of EC.

Indexed as

Endometrial HyperplasiaEndometrial NeoplasmsFibronectinsAdultAgedBiomarkers, TumorCase-Control StudiesCross-Sectional StudiesFemaleHumansMiddle AgedBiomarkers, TumorFibronectinsFNDC5 protein, humanAdipokineEndometrial atypical hyperplasiaEndometrial carcinomaIrisin

Identifiers

PMID41029625
PMCPMC12482771

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.