Evidence map›Paper›PMID 41029907›Full record

ArticlePhysiological reports2025

Effects of habitual endurance and resistance exercise on insulin action in primary human skeletal muscle stem cells.

Polina Krassovskaia, Filip Jevtovic, Donghai Zheng, John Noone, Reichelle X Yeo, Maria F Pino, Cynthia L Stowe, Shannon S Emilson, Nicolas Musi, Kim M Huffman and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Polina KrassovskaiaDepartment of Cancer Biology, Wake Forest University, Winston Salem, North Carolina, USA.ORCID https://orcid.org/0000-0002-6271-3036
Filip JevtovicDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, USA.
Donghai ZhengDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, USA.
John NooneAdventHealth Translational Research Institute, Orlando, Florida, USA.ORCID https://orcid.org/0000-0002-5733-4816
Reichelle X YeoAdventHealth Translational Research Institute, Orlando, Florida, USA.
Maria F PinoAdventHealth Translational Research Institute, Orlando, Florida, USA.
Cynthia L StoweDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Shannon S EmilsonDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Nicolas MusiDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Kim M HuffmanDuke University School of Medicine, Durham, North Carolina, USA.
Caitlin HebertPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Sophia BowenAnschutz Medical Campus, University of Colorado, Aurora, Colorado, USA.ORCID https://orcid.org/0009-0002-0837-0383
Simona ZariniAnschutz Medical Campus, University of Colorado, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0002-7460-3299
Eric RavussinPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0003-2129-547X
Nicholas T BroskeyDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, USA.
William E KraussDuke University School of Medicine, Durham, North Carolina, USA.
Bryan C BergmanAnschutz Medical Campus, University of Colorado, Aurora, Colorado, USA.
Lauren SparksDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, USA.
Joseph A HoumardDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, USA.ORCID https://orcid.org/0000-0003-3682-5410

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · UNIVERSITY OF COLORADO DENVER · 1995 to 2025
$7.7M
HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) AR071128HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK120322NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

Endurance-oriented exercise typically enhances insulin action in skeletal muscle; however, relatively little is known about the impact of resistance exercise. In the present study, insulin action was determined in primary human skeletal muscle stem cells (HSkMCs) isolated from habitual endurance and resistance exercisers and sedentary controls (N = 8-9/group). Insulin action was assessed by insulin-stimulated glycogen synthesis and glucose oxidation using 14C-labeled glucose and insulin signal transduction measured as phosphorylation of Akt (Ser

Indexed as

Endurance TrainingExerciseInsulinInsulin ResistanceMuscle, SkeletalPhysical EnduranceResistance TrainingStem CellsAdultCells, CulturedFemaleGlucoseGlycogenGTPase-Activating ProteinsHumansMaleGlucoseGlycogenGTPase-Activating ProteinsInsulinProto-Oncogene Proteins c-aktTBC1D4 protein, humanexerciseinsulin actioninsulin signalingprimary myotubesskeletal muscle

Identifiers

PMID41029907
PMCPMC12484306

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.