Evidence map›Paper›PMID 41030616›Full record

ArticleFrontiers in cellular neuroscience2025

Distinct reduction in relative microglial glucose uptake compared to astrocytes and neurons upon isolation from the brain environment.

Sebastian T Kunte, Johannes Gnörich, Philipp Beumers, Laura M Bartos, Stephan Wagner, Karin Wind-Mark, Adrien Holzgreve, Dennis Pötter, Rudolf A Werner, Sibylle Ziegler and 4 more

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Astrocytic GPR55 receptors promote glycolysis.Journal of cannabis research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sebastian T KunteDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Johannes GnörichDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Philipp BeumersDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Laura M BartosDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Stephan WagnerDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Karin Wind-MarkDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Adrien HolzgreveDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Dennis PötterDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Rudolf A WernerDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Sibylle ZieglerDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Nathalie L AlbertDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Alessio ColomboGerman Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
Sabina TahirovicGerman Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
Matthias BrendelDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Microglial energy metabolism has gained attention for the treatment of neurodegenerative diseases. Methods: Microglia and astrocytes were isolated from the brain using immunomagnetic cell sorting following [ Results: scRadiotracing results were compared against cell culture [ Discussion: Compared to astrocytes and other cells, microglia show a distinct reduction in uptake in vitro compared to in vivo uptake. Our results emphasize that in vitro experiments should be interpreted with caution when studying microglial energy metabolism.

Indexed as

glucose uptakein vitroin vivomicrogliascRadiotracing

Identifiers

PMID41030616
PMCPMC12477191

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.