ReviewJournal of inflammation research2025
A Focus on the Mechanisms of Alteration in Host Lymphocyte Level Following Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Infection.
Review in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- An Explainable Machine Learning Model for Early Prediction of Incident Myocardial Injury in Patients With Severe Fever With Thrombocytopenia Syndrome.Journal of medical virology · 2026Article
- SFTSV: a priority pathogen in need of a cure-reviewing the therapeutic.Archives of microbiology · 2026Review
- T Follicular Helper Cell Immune Signatures Associated With Disease Severity in Severe Fever With Thrombocytopenia Syndrome.Journal of immunology research · 2026Article
- Multidimensional mechanisms of SFTSV-host interactions: viral protein functions, mFrontiers in cellular and infection microbiology · 2026Review
- Interleukin-6-to-lymphocyte ratio as a novel prognostic factor in patients with severe fever with thrombocytopenia syndrome: a discovery and validation study.Frontiers in immunology · 2026Article
- Characteristics of T-lymphocyte subsets in patients with severe fever with thrombocytopenia syndrome complicated with invasive pulmonary aspergillosis: a retrospective study.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nowadays, severe fever with thrombocytopenia syndrome (SFTS), featuring clinical manifestation of fever with leukopenia, thrombocytopenia and multiple organ function impairment, has been paid more and more attention. It has become the pandemic for a few years and a quantity of people died of it. Severe fever with thrombocytopenia syndrome virus (SFTSV) infection may lead to the development of SFTS, which is characterized by decreased counts of lymphocyte subsets, especially T cells, B cells and natural killer cells, and disruptive release of cytokines, chemokines and growth factors. However, the deeper mechanism of this disease remains unidentified. To excavate the mechanisms of lymphopenia in SFTSV infection and to introduce the potential therapeutics, this paper focuses on lymphopenia as well as reviews the mechanisms and effects of lymphopenia caused by SFTSV infection, mainly through making analogies with other similar viruses to explain the details of programmed cell death. Other factors such as IL-6,IL-10, TNF-α and some vital immunocytes also play significant roles in eliciting lymphopenia. Eventually, the probable clinical implications have been discussed, mentioning that lymphopenia induced by multiple pathways in SFTSV infection may be associated with the severity of viral disease and opportunistic infection.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.