Evidence map›Paper›PMID 41031244›Full record

ArticleBioMed research international2025

In Silico Investigation of Phytochemicals From Clinically Tested Herbal Extracts as Potential Dihydrofolate Reductase Inhibitors for Buruli Ulcer.

Alkhair Adam Khalil Mohamed, Tamekloe Woasiedem, Philip Collins Appiah-Ofori, Esraa Mohammed Abdulmahmoud Adam, Samuel Asiamah Obiri, Lawrence Sheringham Borquaye, Christian K Adokoh, Ghazi Elamin, Isaac Asiamah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alkhair Adam Khalil MohamedDepartment of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana, ucc.edu.gh.ORCID https://orcid.org/0009-0004-1610-8531
Tamekloe WoasiedemDepartment of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana, ucc.edu.gh.ORCID https://orcid.org/0009-0003-1063-5114
Philip Collins Appiah-OforiDepartment of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana, ucc.edu.gh.ORCID https://orcid.org/0009-0002-5319-4518
Esraa Mohammed Abdulmahmoud AdamDepartment of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana, ucc.edu.gh.ORCID https://orcid.org/0009-0003-6405-0963
Samuel Asiamah ObiriDepartment of Chemistry, School of Physical Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana, ucc.edu.gh.ORCID https://orcid.org/0009-0004-5891-2886
Lawrence Sheringham BorquayeDepartment of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID https://orcid.org/0000-0002-5037-0777
Christian K AdokohDepartment of Forensic Sciences, School of Biological Sciences, College of Agriculture and Natural Sciences University of Cape Coast, Cape Coast, Ghana.ORCID https://orcid.org/0000-0002-4341-3361
Ghazi ElaminDepartment of Pharmaceutical Chemistry, College of Pharmacy, Karary University, Khartoum, Sudan, karary.edu.sd.ORCID https://orcid.org/0000-0003-0621-9057
Isaac AsiamahDepartment of Chemistry, School of Physical Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana, ucc.edu.gh.ORCID https://orcid.org/0000-0003-3451-4379

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Buruli ulcer (BU), a neglected tropical disease caused by

Indexed as

Buruli UlcerFolic Acid AntagonistsPhytochemicalsPlant ExtractsTetrahydrofolate DehydrogenaseComputer SimulationHumansMolecular Docking SimulationMolecular Dynamics SimulationMycobacterium ulceransFolic Acid AntagonistsPhytochemicalsPlant ExtractsTetrahydrofolate DehydrogenaseBuruli ulcerdihydrofolate reductase (DHFR)in silico drug discoveryMangifera indicaMD simulationsmolecular dockingMycobacterium ulceransNicotiana tabacumphytochemicals

Identifiers

PMID41031244
PMCPMC12407312

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.