Evidence map›Paper›PMID 41031657›Full record

ReviewJournal of enzyme inhibition and medicinal chemistry2025

Investigation of the potential of phytochemicals derived from citrus peels to inhibit digestive enzymes: an overture to the management of lifestyle diseases.

Lebohang Moloi, Sana Samson, Kadima Tshiyoyo, Kamogelo Maluleke, Marni Oberholzer, Itumeleng Baloyi, Samkelo Malgas

Abstract readReview
In one paragraph

Review in Journal of enzyme inhibition and medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lebohang MoloiDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Hatfield, South Africa.
Sana SamsonDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Hatfield, South Africa.
Kadima TshiyoyoDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Hatfield, South Africa.
Kamogelo MalulekeDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Hatfield, South Africa.
Marni OberholzerDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Hatfield, South Africa.
Itumeleng BaloyiDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Hatfield, South Africa.
Samkelo MalgasDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Hatfield, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The food industry relies on citrus fruits for juice, canned fruit, and jam, creating significant waste from peels, seeds, and pomace. This waste contains valuable phytochemicals like carotenoids, essential oils, (poly)phenols, pectin, and vitamins, which can be used as nutraceuticals or key ingredients in functional foods for managing diabetes and obesity. Repurposing citrus peel waste offers an excellent opportunity to advance biorefineries and the bioeconomy. Compounds derived from citrus have attracted attention for their potential therapeutic effects on diabetes and obesity, and their effectiveness depends on various mechanisms. This review summarises citrus-derived phytochemicals that inhibit α-glucosidase and pancreatic lipase

Indexed as

Anti-Obesity AgentsCitrusEnzyme InhibitorsGlycoside Hydrolase InhibitorsLipasePhytochemicalsalpha-GlucosidasesAnimalsDiabetes Mellitus, Type 2HumansMolecular Docking SimulationMolecular StructureObesityStructure-Activity Relationshipalpha-GlucosidasesAnti-Obesity AgentsEnzyme InhibitorsGlycoside Hydrolase InhibitorsLipasePhytochemicalsCitrus peelsdiabetes mellitusobesityphytochemicalsvalorisation and computational techniques

Identifiers

PMID41031657
PMCPMC12490385

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.