ArticleGigaScience2025
The complete genome assembly of Astragalus membranaceus: enabling more accurate genetic research.
Article in GigaScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Cracking the Hard Seed: Molecular Mechanisms and Multi-Omics Insights into Seed Dormancy and Germination in the GenusInternational journal of molecular sciences · 2026Review
- The complete genome assembly of Astragalus membranaceus: enabling more accurate genetic research.GigaScience · 2025Article
- Mechanistic insights into the antitumor effects of astragaloside IV and astragalus polysaccharide in digestive system cancers.Frontiers in pharmacology · 2025Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundAstragalus membranaceus (Fisch.) Bunge is a globally significant medicinal plant renowned for its potent immunomodulatory and antioxidant properties. However, the existing reference genome for this species remains incomplete, characterized by fragmented assemblies and the absence of centromeric and telomeric regions, thereby limiting comprehensive exploration of the genetic mechanisms underlying its key traits.
findingsWe hereby present the first complete genome assembly for A. membranaceus (Fisch.) Bge "AM-T2T," achieved through the integration of PacBio HiFi, ultra-long Oxford Nanopore Technologies, and Hi-C sequencing. The assembly achieved a total size of 1.39 Gb with an N50 of 180.45 Mb. The genome exhibits remarkable completeness (99.63% BUSCO completeness; long terminal repeat assembly index of 22.67) and high accuracy (quality value of 57.51; Genome Continuity Inspector score of 36.23). It features annotations of 64.22% repetitive sequences, 16 telomeres, 8 centromeres, 32,600 high-confident genes, 248 cytochrome P450 monooxygenases (CYP450s), and 163 uridine diphosphate glycosyltransferases. Notably, 158.58 Mb of previously unassembled regions were resolved, harboring 4 CYP450s. Additionally, 2,267 unique genes and 20,652 conserved genes were identified within the AM-T2T genome. Comparative analysis with Astragalus mongholicus assembly revealed 1,413 structural variations.
conclusionsThis complete genome assembly of A. membranaceus represents a significant advancement in the genomic characterization of A. membranaceus, providing a robust resource that will bolster genetic research, breeding programs, and medicinal applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.