Evidence map›Paper›PMID 41033413›Full record

ArticleBrain stimulation

Transcranial pulse stimulation modulates neuronal activity and functional network dynamics.

Maria Eleni Karakatsani, Irmak Gezginer, Daniil Nozdriukhin, Savannah Tiemann, Hikari A I Yoshihara, Rafael Storz, Markus Belau, Ruiqing Ni, Xosé Luís Deán-Ben, Daniel Razansky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria Eleni KarakatsaniInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093, Zurich, Switzerland.
Irmak GezginerInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093, Zurich, Switzerland.
Daniil NozdriukhinInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093, Zurich, Switzerland.
Savannah TiemannInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093, Zurich, Switzerland.
Hikari A I YoshiharaInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093, Zurich, Switzerland.
Rafael StorzStorz Medical AG, Lohstampfestrasse 8, CH-8274, Tagerwilen, Switzerland.
Markus BelauStorz Medical AG, Lohstampfestrasse 8, CH-8274, Tagerwilen, Switzerland.
Ruiqing NiInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093, Zurich, Switzerland; Institute for Regenerative Medicine, Wagistrasse 12, 9th floor, CH-8952, Zurich, Switzerland.
Xosé Luís Deán-BenInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093, Zurich, Switzerland. Electronic address: xl.deanben@pharma.uzh.ch.
Daniel RazanskyInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093, Zurich, Switzerland. Electronic address: daniel.razansky@uzh.ch.

Funding

Bidirectional optical-acoustic mesoscopic neural interface for image-guided neuromodulation in behaving animalsUF1NS107680 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RAZANSKY, DANIEL, RINBERG, DMITRY · 2018 to 2020
$3.4M
High-Resolution Bidirectional Optical-Acoustic Mesoscopic Neural Interface for Image-Guided Neuromodulation in Behaving Animals - RF1 Admin SupplementRF1NS126102 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CAMPBELL, ROBERT E., RAZANSKY, DANIEL · 2022 to 2024
$3.1M
NINDS NIH HHS RF1 NS126102NINDS NIH HHS UF1 NS107680
6 · The paper itself

Abstract

backgroundTranscranial pulse stimulation (TPS) has recently been proposed as a promising non-invasive technique for treating neurological disorders. While neuropsychological improvements in treated Alzheimer's disease (AD) patients support its safety and preliminary clinical effectiveness, the fundamental mechanisms of TPS action on the brain remain unclear.

objectiveIn this study, we explore the effects of TPS on neuronal activity and brain circuitry in healthy and AD mouse models.

methodsWe utilized fluorescence calcium imaging combined with resting-state functional magnetic resonance imaging and c-Fos immunohistochemistry for validation. We imaged TPS-treated mouse brains expressing genetically encoded calcium indicator and compared the imaging data from AD mouse strains to wild-type controls, followed by immunohistochemical analysis of neuronal activation to support the in vivo imaging findings.

resultsTPS induced robust calcium influxes in GCaMP + mice, increased c-Fos expression in the dentate gyrus, and rapidly but transiently reorganized functional connectivity across brain networks, particularly within the hypothalamus, hippocampus, and other limbic regions. At higher stimulation intensities, TPS is shown to trigger spreading depolarization waves.

conclusionThese findings support the hypothesis that TPS-induced mechanical effects can effectively modulate brain activity while averting tissue heating and cavitation, thus shedding light on observed beneficial effects in patients and paving the way for further optimization of TPS as a therapeutic strategy for neurodegenerative diseases.

Indexed as

Alzheimer DiseaseBrainNerve NetNeuronsTranscranial Direct Current StimulationAnimalsCalciumDisease Models, AnimalMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMice, TransgenicProto-Oncogene Proteins c-fosCalciumProto-Oncogene Proteins c-fosCalcium influxReorganization of functional networkTherapeutic ultrasoundTranscranial pulse stimulation

Identifiers

PMID41033413
PMCPMC13352088

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.