Evidence map›Paper›PMID 41033924›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2025

Neuroprosthetic closed-loop strategy for sustained blood pressure reduction via simultaneous stimulation and recording from the spinal cord.

Mingeun Cho, Minhye Choo, Matthew Koh, Sunguk Hong, Junseung Mun, Juho Koo, ChangHwa Oh, Sung-Min Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mingeun ChoDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea.
Minhye ChooDepartment of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea.
Matthew KohDepartment of Medical Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea.
Sunguk HongDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea.
Junseung MunDepartment of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea.
Juho KooDepartment of Medical Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea.
ChangHwa OhBiomedical Engineering Research Center, Samsung Medical Center, Seoul, 06351, South Korea.
Sung-Min ParkDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea; Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea; Department of Medical Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea; Department of Electrical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea; Division of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, 37673, South Korea. Electronic address: sungminpark@postech.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sympathetic hyperactivity is a common feature observed in both primary and secondary hypertension, and neuromodulation-based therapies targeting this overactivity are under active investigation. The intermediolateral nucleus (IML) in the spinal cord plays a central role in sympathetic regulation, and its direct stimulation induces a transient, frequency-dependent reduction in blood pressure. However, this effect gradually diminishes as the baroreflex restores blood pressure to baseline. Therefore, this study aims to develop a closed-loop (CL) stimulation system that adjusts parameters in real-time based on neural activity recorded from the IML and to enhance and prolong the transient antihypertensive effect. This strategy was evaluated in normotensive and angiotensin II-induced hypertensive rat models and compared to open-loop (OL) stimulation of equal intensity. In both models, CL stimulation produced a more sustained blood pressure reduction than that of OL stimulation. These findings suggest that CL spinal cord stimulation offers a more effective and durable therapeutic option for treating hypertension.

Indexed as

Blood PressureHypertensionSpinal CordSpinal Cord StimulationAnimalsBaroreflexMaleRatsRats, Sprague-DawleyClosed-loopHypertensionNeuromodulationSpinal cord stimulation

Identifiers

PMID41033924
PMCPMC12664564

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.