Evidence map›Paper›PMID 41034302›Full record

ArticleScientific reports2025

Morphological and metabolic alterations in different stages of Alzheimer's diseases: a study using surface-based morphometry (SBM) and amide proton transfer (APT) imaging.

Meimeng Zhong, Qingwei Song, Shuo Zhang, Zhewei Liu, Chang Yuan, Peixue Li, Nan Wang, Dan Yu, Kewei Wang, Chunbo Dong and 3 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Meimeng ZhongDepartment of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Qingwei SongDepartment of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Shuo ZhangDepartment of Nuclear Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Zhewei LiuDepartment of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Chang YuanDepartment of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Peixue LiDepartment of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Nan WangDepartment of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Dan YuUnited Imaging Healthcare, Shanghai, 201815, China.
Kewei WangUnited Imaging Healthcare, Shanghai, 201815, China.
Chunbo DongDepartment of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Jie ZhaoNational-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, 116044, China.
Jing LiuDalian Medical University, Dalian, 116044, China. lj_18@163.com.
Chao YangDepartment of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China. dryangchao@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early diagnosis of Alzheimer's disease (AD) remains a significant challenge due to the lack of objective biomarkers. Accurate identification of morphological and metabolic alterations during the different stages of AD is crucial for timely intervention and effective management of the disease. Surface-based morphometry (SBM) and amide proton transfer (APT) imaging are innovative techniques that offer the potential to visualize these changes in the brain. By leveraging these advanced imaging modalities, this study aims to investigate the specific alterations that occur in AD, thereby exploring potential imaging biomarkers that could facilitate early and precise diagnosis of the condition. The identification of such biomarkers is essential for improving the diagnostic accuracy and efficacy of therapeutic strategies for Alzheimer's disease. In this prospective study, we enrolled 26 patients with AD, thirty-six patients with amnestic mild cognitive impairment (aMCI), and 32 healthy controls (HCs). All participants underwent 3D T1-weighted imaging (T1WI) and 3D-APT imaging. Morphological parameters, including cortical thickness (CTh), sulcal depth (SD), fractal dimension (FD), and gyrification index (GI), were calculated using the SBM algorithm. Magnetization transfer ratio asymmetry (MTR

Indexed as

Alzheimer DiseaseBrainMagnetic Resonance ImagingAgedAmidesCognitive DysfunctionFemaleHumansMaleMiddle AgedProspective StudiesProtonsAmidesProtonsAlzheimer’s diseaseAmide proton transferAmnestic mild cognitive impairmentMagnetic resonance imagingSurface-based morphometry

Identifiers

PMID41034302
PMCPMC12488914

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.