Evidence map›Paper›PMID 41034589›Full record

ArticleNature2025

Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death.

Pavel N Zakharov, Chanchal S Chowdhury, Orion J Peterson, Brady Barron, Anthony N Vomund, Laurent Gorvel, Emil R Unanue, Eynav Klechevsky, Xiaoxiao Wan, Kodi S Ravichandran

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Defective efferocytosis in diabetes: molecular mechanisms and emerging therapeutic strategies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pavel N ZakharovDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA. pzakharov@wustl.edu.
Chanchal S ChowdhuryDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Orion J PetersonDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Brady BarronDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-6938-3789
Anthony N VomundDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Laurent GorvelDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-7526-261X
Emil R UnanueDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Eynav KlechevskyDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-6121-1571
Xiaoxiao WanDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-7439-9374
Kodi S RavichandranDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA. kodi@wustl.edu.ORCID 0000-0001-9049-1410

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
Solute carrier proteins in efferocytosis and inflammationR01AI159551 · NIAID · WASHINGTON UNIVERSITY · PI RAVICHANDRAN, KODI S · 2021 to 2025
$2.9M
Autoimmune Diabetes: Macrophage ResponsesR01AI162591 · NIAID · WASHINGTON UNIVERSITY · PI Xiaoxiao Wan · 2022 to 2026
$2.3M
The Role of CD5 in Tumor ImmunityR01CA245277 · NCI · WASHINGTON UNIVERSITY · PI KLECHEVSKY, EYNAV YAFIT · 2020 to 2024
$1.8M
Harnessing Human Dendritic Cell Subsets in Skin for the Design of Novel ImmunotherapiesR01AR075959 · NIAMS · WASHINGTON UNIVERSITY · PI KLECHEVSKY, EYNAV YAFIT · 2019 to 2023
$1.7M
Solute carrier proteins and metal ion-based signaling during efferocytosisR37AI159551 · NIAID · WASHINGTON UNIVERSITY · PI Kodi S Ravichandran · 2026 to 2026
$611k
NCI NIH HHS R01 CA245277NIAID NIH HHS R01 AI159551NIAID NIH HHS R01 AI162591NIAID NIH HHS R37 AI159551NIAMS NIH HHS R01 AR075959NIDDK NIH HHS P30 DK020579
6 · The paper itself

Abstract

The primary driver of type I diabetes is the autoimmune T cells that destroy insulin-producing β-cells within the islets of Langerhans in the pancreas

Indexed as

ApoptosisInsulin-Secreting CellsIslets of LangerhansMacrophagesPhagocytosisAnimalsCoculture TechniquesDiabetes Mellitus, Type 1FemaleHumansMaleMiceMice, Inbred C57BLMice, Inbred NOD

Identifiers

PMID41034589
PMCPMC12790336

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.