Evidence map›Paper›PMID 41035134›Full record

ArticleAddiction biology2025

PACAP Signalling Network in the Nucleus Accumbens Core Regulates Reinstatement Behaviour in Rat.

Samrat Bose, Gregory Simandl, Evan M Hess, Linghai Kong, Nicholas J Raddatz, Brian Maunze, SuJean Choi, David A Baker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Samrat BoseDepartment of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA.
Gregory SimandlDepartment of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA.
Evan M HessDepartment of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA.
Linghai KongDepartment of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA.
Nicholas J RaddatzDepartment of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA.
Brian MaunzeDepartment of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA.
SuJean ChoiDepartment of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA.
David A BakerDepartment of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA.ORCID 0000-0002-0664-6780

Funding

PACAP-Dependent Coordination of Glutamate Signaling between Neurons and AstrocytesR01DA050180 · NIDA · MARQUETTE UNIVERSITY · PI BAKER, DAVID A · 2020 to 2025
$2.2M
Charles E. Kubly Mental Research CenterJJ Keller FoundationNational Institute on Drug Abuse of the National Institutes of Health R01DA050180NIDA NIH HHS R01 DA050180
6 · The paper itself

Abstract

Cocaine use disorder (CUD) lacks FDA-approved treatments, partly due to the difficulty of creating therapeutics that target behaviour-related neural circuits without disrupting signalling throughout the brain. One promising candidate for circuit-selective neuromodulation is pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide with pleiotropic behavioural actions whose signalling network spans the gut-brain axis. Here, we investigated the potential existence and function of an endogenous PACAP signalling network within the nucleus accumbens core (NAcc), which is a structure that integrates emotional, cognitive and reward processes underlying behaviour. We found that PACAP and its cognate receptor, PAC1R, are endogenously expressed in the rat NAcc and that PACAP mRNA is present in medial prefrontal cortical projections to the NAcc. Behaviourally, intra-NAcc infusions of PACAP

Indexed as

Drug-Seeking BehaviorNucleus AccumbensPituitary Adenylate Cyclase-Activating PolypeptideAnimalsBehavior, AnimalCocaineDopamine Uptake InhibitorsMalePrefrontal CortexRatsRats, Sprague-DawleyReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type ISignal TransductionCocaineDopamine Uptake InhibitorsPituitary Adenylate Cyclase-Activating PolypeptideReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type Icocainedopamine D1‐like dopamine receptor agonistsdopamine D2‐like dopamine receptor agonistsnucleus accumbensPACAPreinstatementself‐administration

Identifiers

PMID41035134
PMCPMC12488396

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.