Evidence map›Paper›PMID 41035657›Full record

ArticleFrontiers in immunology2025

Immunogenetic investigation of WAS patients revealing impaired IL-6/STAT3 signaling in T cells.

Firas Bouzakoura, Najla Mekki, Monia Ben Khaled, Ines Maaloul, Aicha Ben Taieb, Amal Zammeli, Meriem Ben-Ali, Mariem Tira, Ansem Ben-Hammadi, Thouraya Kamoun and 3 more

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Firas Bouzakoura *Laboratory of Transmission, Control and Immunobiology of Infections, LR16IPT02, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
Najla Mekki *Laboratory of Transmission, Control and Immunobiology of Infections, LR16IPT02, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
Monia Ben KhaledFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Ines MaaloulDepartment of Pediatrics, Hedi Chaker University Hospital, Sfax, Tunisia.
Aicha Ben TaiebFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Amal ZammeliLaboratory of Transmission, Control and Immunobiology of Infections, LR16IPT02, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
Meriem Ben-AliLaboratory of Transmission, Control and Immunobiology of Infections, LR16IPT02, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
Mariem TiraLaboratory of Transmission, Control and Immunobiology of Infections, LR16IPT02, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
Ansem Ben-HammadiLaboratory of Transmission, Control and Immunobiology of Infections, LR16IPT02, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
Thouraya KamounDepartment of Pediatrics, Hedi Chaker University Hospital, Sfax, Tunisia.
Monia OuederniFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Mohamed-Ridha BarboucheDepartment of Microbiology, Immunology and Infectious Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama, Bahrain.
Imen Ben-MustaphaLaboratory of Transmission, Control and Immunobiology of Infections, LR16IPT02, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wiskott-Aldrich syndrome (WAS) is an inborn error of immunity caused by loss-of-function mutations in the

Indexed as

Interleukin-6Signal TransductionSTAT3 Transcription FactorT-LymphocytesWiskott-Aldrich SyndromeWiskott-Aldrich Syndrome ProteinChildChild, PreschoolFemaleHumansMaleMutationPhosphorylationSuppressor of Cytokine Signaling 3 ProteinIL6 protein, humanInterleukin-6STAT3 protein, humanSTAT3 Transcription FactorSuppressor of Cytokine Signaling 3 ProteinWiskott-Aldrich Syndrome ProteinDOCK8HIESIL-6STAT3WAS

Identifiers

PMID41035657
PMCPMC12479476

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.