Evidence map›Paper›PMID 41035698›Full record

ArticleFrontiers in cardiovascular medicine2025

Vitamin A deficiency attenuates cardiac rupture in

Yannick Smolenski, Natali Froese, Paolo Galuppo, Christopher Werlein, Anna Gigina, Steven R Talbot, Sergej Erschow, Dirk Wedekind, Robert Geffers, Norbert B Ghyselinck and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Peripartum-Associated Heart Failure Develops Independently of RHOT Proteins.International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yannick Smolenski *Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Natali Froese *Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Paolo GaluppoDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Christopher WerleinInstitute of Pathology, Hannover Medical School, Hannover, Germany.
Anna GiginaDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Steven R TalbotInstitute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.
Sergej ErschowDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Dirk WedekindInstitute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.
Robert GeffersHelmholtz Center for Infection Research, Research Group Genome Analytics, Braunschweig, Germany.
Norbert B GhyselinckInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Département de Génétique Fonctionnelle et Cancer, Centre National de la Recherche Scientifique (CNRS UMR7104), Institut National de la Santé et de la Recherche Médicale (INSERM U1258), Université de Strasbourg, Illkirch, France.
Heike BähreResearch Core Unit Metabolomics, Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
Jan C KampDepartment of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Lavinia NeubertInstitute of Pathology, Hannover Medical School, Hannover, Germany.
Melanie Ricke-HochDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Johann BauersachsDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Christian RiehleDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Stimulated by retinoic acid gene 6 (STRA6) is a cell surface receptor that regulates cellular uptake of vitamin A metabolites and cardiac development. We hypothesized that Methods: MI was induced in mice with Results: Conclusion: The present study identifies an unexpected role for VitAD, which preserves Wnt signaling and attenuates cardiac rupture in

Indexed as

cardiac remodelingheart failuremyocardial infarctionstimulated by retinoic acid gene 6vitamin Awnt signaling

Identifiers

PMID41035698
PMCPMC12479519

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.