ArticleOpen veterinary journal2025
Histopathological and ultrastructural alterations reveal the hepatotoxicity of lead against Moringin: Sub-chronic-chemotherapeutic trial.
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Several researchers in the past have described lead acetate (LA), Pb, as a toxic heavy metal compound that can significantly affect the organs and the body systems, thereby influencing their functions. Aim: This article aimed to look at the negative effects of LA toxicity on rabbit liver samples, detect many histological abnormalities, and then examine the hepatoprotective properties of glucomoringin. Since ancient times, Methods: In this study, 30 rabbits were randomly categorized into three groups, with every group containing 10 rabbits (i.e., Results: The findings in this study indicated that oral LA administration caused significant pathological changes in the livers of the experimental animals which included degeneration, fibrosis, necrosis, inflammation, significant reduction in the plasma catalase and superoxide dismutase activities, and increased plasma malondialdehyde activities. It was hypothesized that the administration of Moringin would mitigate the histopathological changes in the liver tissues. The results indicated that the extract displayed a hepatoprotective effect and considerably reduced the harmful effects of LA on the functions and hepatic tissue. Conclusion: Finally, Moringin is highly efficacious in abating oxidative stress and cellular damage in rabbits.
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