ArticleSurgical endoscopy2025
Effectiveness of transoral endoscopic fundoplication with or without hiatal hernia repair in patients with gerd and chronic cough.
Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Refractory gastroesophageal reflux-related cough: Mechanistic insights and a rational pathway to phenotype-driven management.Therapeutic advances in respiratory diseaseReview
Corrections and comments
- Erratum issued
Authors and funding
18 authors.
Funding
Abstract
aimsGastroesophageal Reflux Disease (GERD) is a common cause of chronic cough. Transoral incisionless fundoplication (TIF) or TIF with concomitant hiatal hernia repair (cTIF) may be suitable treatments. We studied the effectiveness of TIF/cTIF in patients with chronic cough and proven GERD.
methodsPatients with proven GERD from 9 centers (TIF registry) were evaluated before and at a minimum of 6 months post TIF/cTIF. Patients with cough-predominant phenotype were identified (chief complaint of cough and reflux symptom index (RSI) troublesome cough subscore ≥ 2) and compared to those without. The primary outcome was improvement in RSI score compared to baseline. Secondary outcomes were normalization of RSI, improvement in RSI cough sub-scores, GERD symptom improvement, discontinuation of proton pump inhibitor, and patient satisfaction.
resultsOne hundred and ninety-eight patients underwent TIF/cTIF. Follow-up for 177 patients (median 12 months [IQR 6,12]) showed decrease in median RSI score from 18 [IQR 13, 27] to 5 [IQR 2, 11] (p < 0.0001). Eighty-three percent of patients with elevated baseline RSI normalized their scores. Seventy-five percent and 72% had improvement in cough when lying down and troublesome cough, respectively. Eighty-three percent successfully discontinued or decreased PPI. Satisfaction improved from 5.6% at baseline to 68.8% (p < 0.0001). Patients with cough-predominant phenotype (n = 63) experienced an additional 5-point decrease in in RSI score (p = 0.01). Patients with typical GERD symptoms were more likely to have a favorable response for cough symptoms (p < 0.0001).
conclusionTIF/cTIF are effective barrier therapies for patients with cough-predominant pH-positive GERD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.