Evidence map›Paper›PMID 41037843›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2025

Interactions between cardiorespiratory effects of fentanyl and xylazine and their reversal in male and female Sprague-Dawley rats.

Gorana Puzovic, Matthew J Wolan, Yonggong Shi, Gregory T Collins

Abstract read
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Adverse maternal and neonatal effects associated with perinatal xylazine exposure: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gorana PuzovicDepartment of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Matthew J WolanDepartment of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Yonggong ShiDepartment of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Gregory T CollinsDepartment of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas; South Texas Veterans Health Care System, San Antonio, Texas. Electronic address: collinsg@uthscsa.edu.

Funding

Bath Salts: Abuse-related and Toxic EffectsR01DA039146 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Gregory Collins · 2015 to 2026
$4.0M
Integrated Graduate Training Program in Neuroscience, UTHSCSAT32NS082145 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI David A Morilak · 2013 to 2026
$1.5M
NIDA NIH HHS R01 DA039146NINDS NIH HHS T32 NS082145
6 · The paper itself

Abstract

Fentanyl continues to drive overdose deaths in the United States; however, the use of fentanyl adulterated with xylazine, an α

Indexed as

Adrenergic alpha-2 Receptor AgonistsFentanylHeart RateRespiratory RateXylazineAnalgesics, OpioidAnimalsDose-Response Relationship, DrugDrug InteractionsFemaleImidazolesMaleNaloxoneNarcotic AntagonistsRatsRats, Sprague-DawleyAdrenergic alpha-2 Receptor AgonistsAnalgesics, OpioidatipamezoleFentanylImidazolesNaloxoneNarcotic AntagonistsXylazineAtipamezoleCardiorespiratory depressionFentanylNaloxoneRatsXylazine

Identifiers

PMID41037843
PMCPMC13137864

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.