Evidence map›Paper›PMID 41038804›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Enhanced Selenium Supplement Extends Lifespan and Delays Multi-Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis.

Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yang YuHealth Sciences Institute, China Medical University, Shenyang, Liaoning, 110122, China.
Jintao SongHealth Sciences Institute, China Medical University, Shenyang, Liaoning, 110122, China.
Mengjiao GuoHealth Sciences Institute, China Medical University, Shenyang, Liaoning, 110122, China.
RuZe MaDepartment of Gerontology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China.
Mingyang DuHealth Sciences Institute, China Medical University, Shenyang, Liaoning, 110122, China.
Zhe XunHealth Sciences Institute, China Medical University, Shenyang, Liaoning, 110122, China.
Xu LiuHealth Sciences Institute, China Medical University, Shenyang, Liaoning, 110122, China.
RongXia XuHealth Sciences Institute, China Medical University, Shenyang, Liaoning, 110122, China.
Xiaochun XieNational Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong, 510006, China.
Peilin QiHealth Sciences Institute, China Medical University, Shenyang, Liaoning, 110122, China.
Yujie ChenHealth Sciences Institute, China Medical University, Shenyang, Liaoning, 110122, China.
Dan ShaoNational Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong, 510006, China.
Chao YangDepartment of Orthopedics, Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, China.
Liang WangDepartment of Orthopedics, Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, China.
Xiaoyu SongHealth Sciences Institute, China Medical University, Shenyang, Liaoning, 110122, China.
Difei WangDepartment of Gerontology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China.ORCID https://orcid.org/0000-0002-1118-658X

Funding

Application Foundation Plan of Liaoning Science and Technology Department 2022JH1/10400001Application Foundation Plan of Liaoning Science and Technology Department 2023JH2/101600009China Medical University high-quality development project 23-506-3-01-54National Natural Science Foundation of China 12474435National Natural Science Foundation of China 82000827National Natural Science Foundation of China 92249305Overseas Expertise Introduction Project for Discipline Innovation D21008
6 · The paper itself

Abstract

Selenium supplementation has potential in treating aging-related disorders like neurodegenerative and cardiovascular diseases, but its use is limited by poor bioavailability, a narrow therapeutic window, and unclear mechanisms. To overcome this, redox-dual-responsive diselenide-bridged mesoporous silica nanoparticles (SeMSNs) are developed. SeMSNs effectively reduce oxidative stress and downregulate senescence markers (p16, p21), suppressing senescence in both naturally aged primary mouse embryonic fibroblasts (MEFs) and H

Indexed as

AgingCalciumLongevityProtein Serine-Threonine KinasesSeleniumAnimalsDietary SupplementsHEK293 CellsHomeostasisHumansMaleMiceNanoparticlesOxidative StressSignal TransductionCalciumProtein Serine-Threonine KinasesSeleniumagingcalciumnanoparticleseleniumSik1

Identifiers

PMID41038804
PMCPMC12713047

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.