Evidence map›Paper›PMID 41038844›Full record

ArticleNPJ Parkinson's disease2025

Resting and action tremor in Parkinson's disease: pathophysiological insights from long-term STN-DBS.

Alessandro Zampogna, Antonio Suppa, Martina Patera, Francesco Cavallieri, Francesco Bove, Valerie Fraix, Anna Castrioto, Emmanuelle Schmitt, Pierre Pelissier, Stephan Chabardes and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Temporal Dynamics of Parkinson's Disease Tremor: Clinical and Neuroimaging Insights.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alessandro Zampogna *Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Antonio Suppa *Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Martina PateraDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Francesco CavallieriNeurology Unit, Neuromotor and Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Francesco BoveNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy.
Valerie FraixGrenoble Alpes University, Division of Neurology, CHU of Grenoble, Grenoble Institute of Neurosciences, INSERM U1216, Grenoble, France.
Anna CastriotoGrenoble Alpes University, Division of Neurology, CHU of Grenoble, Grenoble Institute of Neurosciences, INSERM U1216, Grenoble, France.
Emmanuelle SchmittGrenoble Alpes University, Division of Neurology, CHU of Grenoble, Grenoble Institute of Neurosciences, INSERM U1216, Grenoble, France.
Pierre PelissierGrenoble Alpes University, Division of Neurology, CHU of Grenoble, Grenoble Institute of Neurosciences, INSERM U1216, Grenoble, France.
Stephan ChabardesGrenoble Alpes University, Division of Neurosurgery, CHU of Grenoble, Grenoble, France.
Sara MeoniGrenoble Alpes University, Division of Neurology, CHU of Grenoble, Grenoble Institute of Neurosciences, INSERM U1216, Grenoble, France.
Elena MoroGrenoble Alpes University, Division of Neurology, CHU of Grenoble, Grenoble Institute of Neurosciences, INSERM U1216, Grenoble, France. emoro@chu-grenoble.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tremor is a well-recognized sign of Parkinson's disease (PD), yet its long-term evolution remains unclear, particularly regarding the relationship between resting and action tremor. This retrospective study examined resting and action tremor using specific UPDRS-III subitems in 301 PD patients treated with bilateral subthalamic nucleus deep brain stimulation (STN-DBS), assessed preoperatively and at one-year follow-up, with 108 and 57 patients re-evaluated at ten and 15 years, respectively. Most patients (61.8%) had both tremor types, with smaller subsets showing isolated resting (14.3%), action (10.6%), or no tremor (13.3%). Resting tremor responded better to L-Dopa, STN-DBS, and their combination than action tremor (p < 0.05) and remained stable long-term. In contrast, action tremor worsened over time, particularly in tremor-dominant and mixed phenotypes (p < 0.05). A moderate association between tremor types was observed OFF-medication (ρ = 0.59), weakening under treatment (ρ = 0.23/0.30). Action tremor also correlated weakly with bradykinesia and rigidity (ρ = 0.19/0.21). Overall, these differences suggest distinct pathophysiology and neural circuits for resting and action tremor in PD.

Identifiers

PMID41038844
PMCPMC12491427

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.