Evidence map›Paper›PMID 41039621›Full record

ArticleInternational journal of retina and vitreous2025

Quantification of intermittent retinal capillary perfusion in retinal vein occlusion and proliferative diabetic retinopathy.

Mahadev Bhalla, Farhad Ghaseminejad, Taylor Burdett, Arman Athwal, Brendan Tao, Marinko V Sarunic, Rony C Preti, Eduardo V Navajas

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In one paragraph

Article in International journal of retina and vitreous, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Mahadev Bhalla *Department of Ophthalmology and Vision Sciences, Eye Care Centre, University of British Columbia, Vancouver, BC, Canada.
Farhad Ghaseminejad *Department of Ophthalmology and Vision Sciences, Eye Care Centre, University of British Columbia, Vancouver, BC, Canada.
Taylor BurdettDepartment of Medical Physics, Biomedical Engineering, University College London, London, England.
Arman AthwalDepartment of Medical Physics, Biomedical Engineering, University College London, London, England.
Brendan TaoDepartment of Ophthalmology and Vision Sciences, Eye Care Centre, University of British Columbia, Vancouver, BC, Canada.
Marinko V SarunicDepartment of Medical Physics, Biomedical Engineering, University College London, London, England.
Rony C PretiDepartment of Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil.
Eduardo V NavajasDepartment of Ophthalmology and Vision Sciences, Eye Care Centre, University of British Columbia, Vancouver, BC, Canada. edunavajas@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo detect and quantify intermittent capillary perfusion using optical coherence tomography angiography (OCTA) in patients with branch retinal vein occlusion (BRVO), central retinal vein occlusion (CRVO), proliferative diabetic retinopathy (PDR), and healthy control eyes.

methodsOCTA images were acquired from patients with BRVO(n = 9), CRVO(n = 8), PDR(n = 8) and healthy controls(n = 10). Five 6 × 6 mm scans were registered and averaged at baseline (T0) and thirty minutes after (T30) into single en-face images of the superficial and deep vascular complexes (SVC and DVC). Pixels were labeled as vessel or non-vessel using a previously published machine learning model. Loss of Perfusion (LoP) was defined as the percentage of vessel pixels present in T0 image that disappeared at T30, and Gain of Perfusion (GoP) was defined as the percentage of vessel pixels that appeared in T30 image. The amount of intermittent capillary perfusion was the sum of GoPLoP.

resultsPatients with PDR, CRVO and BRVO showed significantly higher GoPLoP values than controls in both the macular and temporal regions. The temporal region generally exhibited significantly greater GoPLoP values than the macular region. Layer analysis indicated a significantly higher GoPLoP within the DVC compared to the SVC. There was a significant negative correlation between perfusion density and perfusion variability.

conclusionOur results demonstrate higher GoPLoP in BRVO, CRVO, and PDR patients compared to controls. This measure may be utilized as a novel biomarker of tissue hypoxia. Further studies are necessary to better elucidate the role of GoPLoP in monitoring disease progression and treatment efficacy of retinal vascular diseases.

Indexed as

Intermittent capillary perfusionOptical coherence tomography angiographyProliferative diabetic retinopathyRetinal vein occlusion

Identifiers

PMID41039621
PMCPMC12492569

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.