Evidence map›Paper›PMID 41040184›Full record

ArticlebioRxiv : the preprint server for biology2025

Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning.

Zukai Liu, Chengxiang Qiu, Connor A Kubo, Stella Xu, Riza M Daza, Eva Nichols, Wei Yang, Anh Vo, Mary B O'Neill, Choli Lee and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zukai LiuDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Chengxiang QiuDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Connor A KuboDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Stella XuInstitute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.
Riza M DazaDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Eva NicholsDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Wei YangDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Anh VoSeattle Hub for Synthetic Biology, Seattle, WA, USA.
Mary B O'NeillSeattle Hub for Synthetic Biology, Seattle, WA, USA.
Choli LeeDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Jay ShendureDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Nobuhiko HamazakiDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.

Funding

UW 4-Dimensional Genomic Organization of Mammalian Embryogenesis CenterUM1HG011586 · NHGRI · UNIVERSITY OF WASHINGTON · PI DISTECHE, CHRISTINE M., NOBLE, WILLIAM STAFFORD · 2020 to 2024
$10.3M
Versatile, exponentially scalable methods for single cell molecular profilingR01HG010632 · NHGRI · UNIVERSITY OF WASHINGTON · PI Jay Ashok Shendure, Bruce Colston Trapnell · 2019 to 2026
$5.9M
NHGRI NIH HHS R01 HG010632NHGRI NIH HHS UM1 HG011586
6 · The paper itself

Abstract

Human gastruloids are a powerful class of stem cell-derived models that recapitulate key features of early embryonic development, including symmetry breaking and the emergence of three germ layers

Identifiers

PMID41040184
PMCPMC12485718

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.