Evidence map›Paper›PMID 41040211›Full record

ArticlebioRxiv : the preprint server for biology2025

PIP4K attenuates PIP5K lipid kinase activity by disrupting membrane-mediated dimerization.

Benjamin R Duewell, Michael J Chirumbolo, Samantha M Fernandez-Ortiz, Gerald R V Hammond, Scott D Hansen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Benjamin R DuewellDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403.
Michael J ChirumboloDepartment of Cell Biology, University of Pittsburgh School of Medicine; Pittsburgh, PA 15261, USA.
Samantha M Fernandez-OrtizDepartment of Biology, University of Oregon, Eugene, OR 97403.
Gerald R V HammondDepartment of Cell Biology, University of Pittsburgh School of Medicine; Pittsburgh, PA 15261, USA.ORCID 0000-0002-6660-3272
Scott D HansenDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403.ORCID 0000-0001-7005-6200

Funding

MOLECULAR BIOLOGY AND BIOPHYSICST32GM007759 · NIGMS · UNIVERSITY OF OREGON · PI NOLEN, BRADLEY J · 1985 to 2021
$8.5M
Directing Membrane Function with Inositol Lipids in Health and DiseaseR35GM119412 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gerald R Hammond · 2016 to 2026
$4.3M
NIGMS NIH HHS R35 GM119412NIGMS NIH HHS T32 GM007759
6 · The paper itself

Abstract

The phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family of enzymes generate most of the phosphatidylinositol-4,5-bisphosphate (PI(4,5)P

Identifiers

PMID41040211
PMCPMC12485675

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.