Evidence map›Paper›PMID 41040223›Full record

ArticlebioRxiv : the preprint server for biology2025

Gasdermin C links nutrient and immune signaling to protist-induced type 2 immunity and intestinal repair.

Andrea Keller, Ayobami Adeniyi, Kübra B Akkaya-Colak, Maria Festing, Andrew Schwieters, Rathan Kumar, James Sledziona, Khushboo Gupta, Patrick Stevens, Maciej Pietrzak and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andrea KellerDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Ayobami AdeniyiDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Kübra B Akkaya-ColakDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Maria FestingDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Andrew SchwietersDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA.
Rathan KumarDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.
James SledzionaDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Khushboo GuptaDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Patrick StevensDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.
Maciej PietrzakDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.
Vincenzo CoppolaDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210, USA.
Parvathi RanganathanDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.
Brian AhmerDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA.
Adriana ForeroDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA.
Sue E KnoblaughDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Maria M MihaylovaDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Cellular, molecular, and biochemical sciences training grantT32GM141955 · NIGMS · OHIO STATE UNIVERSITY · PI Jane Elizabeth Jackman, JESSE J KWIEK · 2021 to 2026
$2.2M
Multidisciplinary Training in Ethnic Diversity and Cancer DisparitiesT32CA229110 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2019 to 2023
$2.1M
Training Program For Cancer Prevention and ControlT32CA229114 · NCI · OHIO STATE UNIVERSITY · PI Chyke Abadama Doubeni, Peter G. Shields · 2018 to 2026
$2.0M
Identification of novel type III IFN regulatory pathwaysR35GM150806 · NIGMS · OHIO STATE UNIVERSITY · PI Adriana Forero · 2023 to 2026
$1.6M
Understanding the Mechanisms of Age-Dependent Decline of Intestinal Stem Cell FunctionR00AG054760 · NIA · OHIO STATE UNIVERSITY · PI MIHAYLOVA, MARIA M. · 2018 to 2020
$747k
NCI NIH HHS P30 CA016058NCI NIH HHS T32 CA229110NCI NIH HHS T32 CA229114NIA NIH HHS R00 AG054760NIGMS NIH HHS R35 GM150806NIGMS NIH HHS T32 GM141955
6 · The paper itself

Abstract

The Gasdermin family of proteins has recently been implicated in tissue repair and homeostasis through their effector function in type 2 immunity and pyroptosis. Yet the role of Gasdermin C proteins has not been fully characterized in the mammalian intestine, where environmental factors can influence epithelial regeneration and repair. Here we report that

Indexed as

commensal protistsGasdermin Cintestinal barriermicrobiome-host interactionsnutrient sensingSTAT6type 2 immunity

Identifiers

PMID41040223
PMCPMC12485678

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.