Evidence map›Paper›PMID 41040727›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Type-2 immune skewing in patients with disseminated coccidioidomycosis.

Timothy J Thauland, Smriti S Nagarajan, Alexis V Stephens, Samantha L Jensen, Anviksha Srivastava, Miguel A Moreno Lastre, Terrie S Ahn, Chantana Bun, Michael T Trump, Royce H Johnson and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Timothy J ThaulandDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, UCLA, Los Angeles, CA USA.ORCID 0000-0003-4121-0453
Smriti S NagarajanDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, UCLA, Los Angeles, CA USA.
Alexis V StephensDepartment of Medical Microbiology and Immunology, University of California, Davis, Sacramento, CA, USA.
Samantha L JensenDepartment of Medical Microbiology and Immunology, University of California, Davis, Sacramento, CA, USA.
Anviksha SrivastavaDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, UCLA, Los Angeles, CA USA.
Miguel A Moreno LastreDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, UCLA, Los Angeles, CA USA.
Terrie S AhnDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, UCLA, Los Angeles, CA USA.
Chantana BunDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, UCLA, Los Angeles, CA USA.
Michael T TrumpDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, UCLA, Los Angeles, CA USA.
Royce H JohnsonDivision of Infectious Diseases, Department of Medicine, Kern Medical Center, Bakersfield, CA.
George R ThompsonDivision of Infectious Diseases, Department of Medicine, University of California, Davis, Sacramento, CA, USA.ORCID 0000-0001-8518-5750
Maria I Garcia-LloretDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, UCLA, Los Angeles, CA USA.
Valerie A ArboledaDepartment of Human Genetics, UCLA, Los Angeles, CA USA.ORCID 0000-0002-9687-9122
Manish J ButteDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, UCLA, Los Angeles, CA USA.ORCID 0000-0002-4490-5595

Funding

Innate immune mechanisms of the host response to CoccidioidesU19AI166059 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Royce Harwood Johnson · 2022 to 2026
$10.0M
T-cell Dysfunction as the basis of Disseminated CoccidioidomycosisR21AI149654 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUTTE, MANISH J · 2021 to 2022
$421k
NIAID NIH HHS R21 AI149654NIAID NIH HHS U19 AI166059
6 · The paper itself

Abstract

Background: Disseminated coccidioidomycosis (DCM) is an often fatal and otherwise intractable condition requiring lifelong antifungal treatment. We have previously shown that a deranged polarization of CD4 Methods: We collected peripheral blood mononuclear cells from 204 patients with coccidioidomycosis, including 96 patients with disseminated disease. We measured immune phenotypes and cytokine production by CD4 Results: We found that ~20% of DCM patients had a CD4 Conclusion: Patients with DCM, especially those who are male, should be screened for Type-2 skewing of CD4

Identifiers

PMID41040727
PMCPMC12486045

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.