Evidence map›Paper›PMID 41041518›Full record

ReviewOpen medicine (Warsaw, Poland)2025

Supplement strategies for infertility in overweight women: Evidence and legal insights.

Giuseppe Gullo, Eleonora Conti, Valentina Billone, Elena Chitoran, Karolina Kowalcze, Robert Krysiak, Alberto Vaiarelli, Romualdo Sciorio, Stamatios Petousis, Yuliia Kotlik and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Open medicine (Warsaw, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giuseppe GulloDepartment of Obstetrics and Gynaecology, AOOR Villa Sofia - Cervello, University of Palermo, Palermo, Italy.
Eleonora ContiDepartment of Obstetrics and Gynaecology, AOOR Villa Sofia - Cervello, University of Palermo, Palermo, Italy.
Valentina BilloneDepartment of Obstetrics and Gynaecology, AOOR Villa Sofia - Cervello, University of Palermo, Palermo, Italy.
Elena ChitoranGeneral Surgery and Surgical Oncology Department I, Bucharest Institute of Oncology "Al. Trestioreanu", 022328, Bucharest, Romania.
Karolina KowalczeDepartment of Pathophysiology, Faculty of Medicine, Academy of Silesia, 40-555, Katowice, Poland.
Robert KrysiakDepartment of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, 40-752, Katowice, Poland.
Alberto VaiarelliIVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Rome, Italy.
Romualdo SciorioFertility Medicine and Gynaecological Endocrinology Unit, Department Woman Mother Child, Lausanne University Hospital, 1011, Lausanne, Switzerland.
Stamatios Petousis2nd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, 541-24, Thessaloniki, Greece.
Yuliia KotlikDepartment of Obstetrics and Gynaecology, AOOR Villa Sofia - Cervello, University of Palermo, Palermo, Italy.
Antonio PerinoDepartment of Obstetrics and Gynaecology, AOOR Villa Sofia - Cervello, University of Palermo, Palermo, Italy.
Gaspare CucinellaDepartment of Obstetrics and Gynaecology, AOOR Villa Sofia - Cervello, University of Palermo, Palermo, Italy.
Susanna MarinelliSchool of Law, Polytechnic University of Marche, 60121 Ancona, Italy.
Lina De PaolaDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00161, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Infertility is a multifactorial condition that affects both men and women and is influenced by various factors, including overweight and obesity. These conditions, especially in women with polycystic ovary syndrome (PCOS), are strongly associated with hormonal and metabolic imbalances that can impair fertility. Targeted nutritional interventions, such as nutraceutical supplementation, may offer support in improving reproductive outcomes. Methods: A narrative review was conducted using PubMed, focusing on publications from the past 12 years with the keywords "nutraceutical," "overweight," and "infertility." The review aimed to identify the main nutraceuticals used in managing infertility and to highlight the importance of a personalized approach tailored to individual patient characteristics. Results: Nutraceuticals may represent a safe and cost-effective adjunctive strategy to support fertility in overweight patients, particularly in those with PCOS. Evidence suggests that their effectiveness increases when integrated into a personalized treatment plan based on individual needs and clinical profiles. Conclusions: This review offers an updated overview of nutraceutical use in overweight individuals with infertility, outlining both benefits and limitations. It also addresses the often-overlooked medico-legal aspects of prescribing nutraceuticals, emphasizing the need for ethical and legal awareness when incorporating these interventions into clinical practice.

Indexed as

medico-legal implicationsnutraceuticalobese female patientsreproductive dysfunction

Identifiers

PMID41041518
PMCPMC12487767

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.