Evidence map›Paper›PMID 41041571›Full record

ArticleResearch square2025

Polyunsaturated fatty acid balance modulates microglial state in a murine model of oxygen-induced neovascularization.

Esther S Kim, Meng-Chin Lin, Cheng-Hsiang Lu, David Casero, Brian Aguirre, Joanne Brown, Olawande Olagoke, Camilia R Martin, Madhuri Wadehra, Kara L Calkins and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Esther S KimDepartment of Pediatrics, Olive View-UCLA Medical Center, 14445 Olive View Drive, Sylmar, CA, 91342, USA.
Meng-Chin LinDivision of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095.
Cheng-Hsiang LuF. Widjaja Inflammatory Bowel Dise ase Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048.
David CaseroF. Widjaja Inflammatory Bowel Dise ase Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048.
Brian AguirreDepartment of Pathology Lab Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095.
Joanne BrownDepartment of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Olawande OlagokeDepartment of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Camilia R MartinDivision of Neonatology, Department of Pediatrics, Weill Cornell Medicine, New York, NY 10065.
Madhuri WadehraDepartment of Pathology Lab Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095.
Kara L CalkinsDivision of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095.
Alison ChuDivision of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Vision Science Training ProgramT32EY007026 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alapakkam P Sampath · 1985 to 2026
$5.7M
Targeting epithelial membrane protein 2 (EMP2) in retinopathy of prematurityR01EY032561 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHU, ALISON · 2021 to 2025
$2.0M
NCATS NIH HHS UL1 TR001881NEI NIH HHS R01 EY032561NEI NIH HHS T32 EY007026
6 · The paper itself

Abstract

The Oxygen-Induced Retinopathy (OIR) model is a widely used research tool to study pathological retinal neoangiogenesis observed in the development of diseases like retinopathy of prematurity (ROP) and proliferative diabetic retinopathy. While many factors are known to modulate susceptibility to OIR development, less is understood about how nutritional factors such as dietary fatty acids affect disease progression. The retina is enriched in polyunsaturated fatty acids (PUFAs) which are indispensable for normal vision, and recent work has shown that dietary supplementation of ω-6-and ω-3-polyunsaturated fatty acids (PUFAs) can provide a protective role against the pathological neovascularization observed in ROP. In the current study, we interrogated the effects of endogenous ω-3-PUFA enrichment using transgenic

Indexed as

angiogenesishypoxiamicrogliaoxygen-induced retinopathypolyunsaturated fatty acidsretinaretinopathy of prematurity

Identifiers

PMID41041571
PMCPMC12486074

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.